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phosphoric acid mono- (3- (4- benzyloxyphenyl)- 2- octadec- 9- enoylaminopropyl) ester

a dual LPA1 and LPA3 receptor antagonist; a radiation protective agent

Also Known As:

VPC 12249; VPC-12249; VPC12249

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Monounsaturated Fatty Acids: 676
      - Oleic Acids: 67
        phosphoric acid mono-(3-(4-benzyloxyphenyl)-2-octadec-9-enoylaminopropyl) ester: 3
Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphates: 1942
    - phosphoric acid mono-(3-(4-benzyloxyphenyl)-2-octadec-9-enoylaminopropyl) ester: 3

Experts

1.	Dedoni, Simona: 1 article (11/2016)
2.	Olianas, Maria C: 1 article (11/2016)
3.	Onali, Pierluigi: 1 article (11/2016)
4.	Cong, Cuicui: 1 article (09/2014)
5.	Mao, Lijun: 1 article (09/2014)
6.	Xu, Xixian: 1 article (09/2014)
7.	Zhang, Yanlin: 1 article (09/2014)
8.	Zhao, Jinyuan: 1 article (09/2014)
9.	Zhao, Zanmei: 1 article (09/2014)
10.	Huang, Liping: 1 article (09/2003)

Related Diseases

1.	Silicosis 09/01/2014 - "In this study, we evaluated the hypothesis that LPA and LPA1/3 may play a role in silicosis pathogenesis using rat silicosis models induced by intratracheal instillation of silica, and randomly divided into control, silica, and VPC-12249 groups. " 09/01/2014 - "In vivo and in vitro experiments revealed that α-SMA expression and collagen deposition reduced significantly after VPC-12249 treatment, and histopathological results show VPC-12249 alleviates silicosis progression. "
2.	Acute Kidney Injury (Acute Renal Failure) 09/01/2003 - "We conclude that VPC-12249 reduces renal I/R injury predominantly by LPA3 receptor blockade and could serve as a novel compound in the treatment of ischemia acute renal failure."
3.	Ischemia 09/01/2003 - "We conclude that VPC-12249 reduces renal I/R injury predominantly by LPA3 receptor blockade and could serve as a novel compound in the treatment of ischemia acute renal failure."
4.	Glioma (Gliomas) 11/01/2016 - "Thus, in C6 glioma cells and rat cortical astrocytes, ERK1/2 activation induced by either amitriptyline or mianserin was antagonized by Ki16425 and VPC 12249 (S), which block LPA1 and LPA3 receptors, and by AM966, which selectively blocks LPA1 Cell depletion of LPA1 with siRNA treatment markedly reduced antidepressant- and LPA-induced ERK1/2 phosphorylation. "

Related Drugs and Biologics

1.	Silicon Dioxide (Silica)
2.	Lysophosphatidic Acid Receptors
3.	Small Interfering RNA (siRNA)
4.	Mianserin
5.	Collagen
6.	Antidepressive Agents (Antidepressants)
7.	Amitriptyline (Elavil)
8.	3- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid