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SSJ 127

an antimalarial; structure in first source

Also Known As:

SSJ-127; SSJ127

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        SSJ 127: 1
    - Oxazoles: 89
      - SSJ 127: 1
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzothiazoles: 40
      - SSJ 127: 1

Experts

1.	Arai, Chika: 1 article (11/2010)
2.	Ihara, Masataka: 1 article (11/2010)
3.	Ikegami-Kawai, Mayumi: 1 article (11/2010)
4.	Ogawa, Yuko: 1 article (11/2010)
5.	Yanoshita, Ryohei: 1 article (11/2010)

Related Diseases

1.

11/15/2010 - "These results raised the possibility that SSJ-127 accumulates in an apicoplast of the malaria parasite and affects protozoan parasite-specific pathways."
11/15/2010 - "Selective accumulation of SSJ-127 in an organelle is observed in all blood stages of live malaria parasites. "
11/15/2010 - "SSJ-127 was detected by fluorescence microscopy in the mouse malaria parasites Plasmodium berghei after exposure of infected red blood cells to the compound in vitro and in vivo. "
11/15/2010 - "SSJ-127, a novel antimalarial rhodacyanine derivative, has shown potent antimalarial activity against chloroquine-resistant Plasmodium strains in vitro and subcutaneous administration of SSJ-127 results in a complete cure of a mouse malaria model. "

Related Drugs and Biologics

1.	Chloroquine (Aralen)
2.	Antimalarials (Antimalarial Agents)
3.	rhodacyanine