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KST 5468

a T-type calcium channel antagonist; structure in first source

Also Known As:

KST-5468; KST5468

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Isoxazoles: 155
      - KST 5468: 1
  - Piperazines: 26
    - KST 5468: 1

Experts

1.	Choo, Hyunah: 1 article (12/2010)
2.	Chung, Hye Jin: 1 article (12/2010)
3.	Kim, Hyun Jeong: 1 article (12/2010)
4.	Koh, Hun Yeong: 1 article (12/2010)
5.	Lee, Jie Eun: 1 article (12/2010)
6.	Lee, Min Ju: 1 article (12/2010)
7.	Lee, Sang Chul: 1 article (12/2010)
8.	Pae, Ae Nim: 1 article (12/2010)
9.	Shin, Teo Jeon: 1 article (12/2010)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 12/01/2010 - "Taken together, the results of this study suggest that KST5468 may be an effective antinociceptive agent for neuropathic pain." 12/01/2010 - "Moreover, in two neuropathic pain models induced by chronic constriction and spared nerve injury, KST5468 significantly increased the mechanical pain threshold. " 12/01/2010 - "KST5468, a new T-type calcium channel antagonist, has an antinociceptive effect on inflammatory and neuropathic pain models." 12/01/2010 - "The new synthetic compound may have an antinociceptive effect, and thus we evaluated KST5468 as a putative analgesic in a hot plate test, a formalin test, and two neuropathic pain models. "
2.	Pain (Aches) 12/01/2010 - "Interestingly, in the second phase of formalin test, KST5468 decreased pain behaviors in a dose-dependent manner. " 12/01/2010 - "Using immunohistochemistry, expression of two well known pain-related molecular markers, c-Fos and calcitonin gene-related peptide (CGRP), and phosphorylated extracellular signal-related kinase (p-ERK) were found to be decreased in the laminae I-II layers of the ipsilateral L4-L5 spinal dorsal horn in KST5468 treated mice. "

Related Drugs and Biologics

1.	T-Type Calcium Channels (T-Type Calcium Channel)
2.	Calcitonin Gene-Related Peptide
3.	Phosphotransferases (Kinase)
4.	Formaldehyde (Formol)
5.	Analgesics (Analgesic Drugs)