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dimethylsulfoxonium methylide

structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Sulfur Compounds: 278
  - Sulfonium Compounds: 1
    - dimethylsulfoxonium methylide: 2
- Onium Compounds
  - Sulfonium Compounds: 1
    - dimethylsulfoxonium methylide: 2

Experts

1.	Kawasaki, Ikuo: 2 articles (07/2007 - 02/2003)
2.	Ohta, Shunsaku: 2 articles (07/2007 - 02/2003)
3.	Yamashita, Masayuki: 2 articles (07/2007 - 02/2003)
4.	Kurume, Ai: 1 article (07/2007)
5.	Miyatake, Akemi: 1 article (07/2007)
6.	Murai, Kousuke: 1 article (07/2007)
7.	Sawaki, Takeshi: 1 article (07/2007)
8.	Sugimoto, Yasuko: 1 article (07/2007)
9.	Takahara, Ayano: 1 article (07/2007)
10.	Takao, Ikuko: 1 article (07/2007)

Related Diseases

1.

Melanoma (Melanoma, Malignant)

07/20/2007 - "The first asymmetric total synthesis of (-)-Linderol A, a potent inhibitor of melanin biosynthesis of cultured B-16 melanoma cells, has been achieved via two key reactions: a diastereoselective [2+2] photocycloaddition of a coumarin-3-carboxylate bearing a chiral auxiliary with 3-methyl-1-butene and a subsequent stereoconvergent transformation of the photoadducts with use of dimethylsulfoxonium methylide to afford a tetrahydrodibenzofuran derivative."
02/21/2003 - "The first total synthesis of (+/-)-Linderol A, a hexahydrodibenzofuran constituent of Lindera umbellata bark, with potent inhibitory activity on the melanin biosynthesis of cultured B-16 melanoma cells, was achieved through 19 steps of reaction in 6.6% overall yield, in which the critical step was a tandem reaction of a 3-ethoxycarbonylcoumarin derivative with dimethylsulfoxonium methylide to yield the 2-ethoxycarbonylcyclopenta[b]benzofuran-3-ol derivative."

Related Drugs and Biologics

1.	Melanins (Melanin)
2.	linderol A
3.	benzofuran
4.	coumarin-3-carboxylic acid