HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

GO-CoA-Tat

a peptide-based bisubstrate analog that antagonizes ghrelin O-acyltransferase (GOAT); structure in first source

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - GO-CoA-Tat: 5

Experts

1.	Cole, Philip A: 2 articles (04/2013 - 12/2010)
2.	Hwang, Yousang: 2 articles (04/2013 - 12/2010)
3.	Fan, Xiaoming: 1 article (01/2018)
4.	Mao, Yuqing: 1 article (01/2018)
5.	Zhang, Shaoren: 1 article (01/2018)
6.	Li, Ziru: 1 article (03/2016)
7.	Mulholland, Michael: 1 article (03/2016)
8.	Zhang, Weizhen: 1 article (03/2016)
9.	Bartness, Timothy J: 1 article (04/2013)
10.	Garretson, John T: 1 article (04/2013)

Related Diseases

1.	Weight Gain 04/01/2013 - "The GOAT inhibitor, GO-CoA-Tat, decreases the circulating concentrations of octanoylated ghrelin and attenuates weight gain on a high fat diet in mice. " 12/17/2010 - "Intraperitoneal administration of GO-CoA-Tat improves glucose tolerance and reduces weight gain in wild-type mice but not in ghrelin-deficient mice, supporting the concept that its beneficial metabolic effects are due specifically to GOAT inhibition. " 03/01/2016 - "GO-CoA-Tat, a peptide GOAT inhibitor, attenuates acyl-ghrelin production and prevents weight gain induced by a medium-chain triglycerides-rich high fat diet. "
2.	Non-alcoholic Fatty Liver Disease 01/01/2018 - "A chronic NAFLD model was established by feeding male mice C57bl/6 with high-fat diet (HFD) for 56 days with GO-CoA-Tat administrated subcutaneously. " 01/01/2018 - "These results indicate that the inhibition of GOAT attenuates lipotoxicity by autophagy stimulation via AMPK-mTOR restoration and offers innovative evidence for using GO-CoA-Tat or siRNA-GOAT in NAFLD clinically."
3.	Weight Loss (Weight Reduction) 11/01/2010 - "The compound GO-CoA-Tat was studied in vitro and in vivo; after intraperitoneal administration, it enhances insulin response to a glucose load and leads to a statistically significant weight loss in mouse fed with a high fat diet."
4.	Metabolic Diseases (Metabolic Disease) 12/17/2010 - "In addition to serving as a research tool for mapping ghrelin actions, GO-CoA-Tat may help pave the way for clinical targeting of GOAT in metabolic diseases."

Related Drugs and Biologics

1.	Ghrelin
2.	Glucose (Dextrose)
3.	Small Interfering RNA (siRNA)
4.	Triglycerides (Triacylglycerol)
5.	Peptides (Polypeptides)
6.	Insulin (Novolin)
7.	acyl-ghrelin