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ethyl 5- amino- 2- methyl- 6,7,8,9- tetrahydrobenzo(b)(1,8)naphthyridine- 3- carboxylate

structure in first source

Also Known As:

ITH12246; ethyl AMTNC

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Naphthyridines: 2
      - ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo(b)(1,8)naphthyridine-3-carboxylate: 1

Experts

1.	Estrada, Martín: 1 article (09/2013)
2.	González-Lafuente, Laura: 1 article (09/2013)
3.	Lajarín-Cuesta, Rocío: 1 article (09/2013)
4.	Lorrio, Silvia: 1 article (09/2013)
5.	López, Manuela G: 1 article (09/2013)
6.	Marco-Contelles, Jose: 1 article (09/2013)
7.	Martínez-Sanz, Francisco J: 1 article (09/2013)
8.	Rodríguez-Franco, María Isabel: 1 article (09/2013)
9.	Romero, Alejandro: 1 article (09/2013)
10.	Samadi, Abdelouahid: 1 article (09/2013)

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease) 09/18/2013 - "All of these findings allow us to consider ITH12246 as a new potential drug for the treatment of neurodegenerative diseases, which would act as a multifactorial neuroprotectant. "
2.	Memory Disorders (Memory Loss) 09/18/2013 - "We decided to investigate the pharmacological properties of ITH12246, evaluating its ability to counteract the memory impairment evoked by scopolamine, a muscarinic antagonist described to promote memory loss, as well as to reduce the infarct volume in mice suffering phototrombosis. "
3.	Infarction (Infarctions) 09/18/2013 - "Its potential hepatotoxicity was observed only at very high concentrations, from 0.1 mM. ITH12246, at the concentration of 10 mg/kg i.p., was able to improve the memory index of mice treated with scopolamine, from 0.22 to 0.35, in a similar fashion to the well-known Alzheimer's disease drug galantamine 2.5 mg/kg. On the other hand, ITH12246, at the concentration of 2.5 mg/kg, reduced the phototrombosis-triggered infarct volume by 67%. " 09/18/2013 - "We decided to investigate the pharmacological properties of ITH12246, evaluating its ability to counteract the memory impairment evoked by scopolamine, a muscarinic antagonist described to promote memory loss, as well as to reduce the infarct volume in mice suffering phototrombosis. "
4.	Brain Ischemia (Cerebral Ischemia) 09/18/2013 - "PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice."
5.	Alzheimer Disease (Alzheimer's Disease) 09/18/2013 - "ITH12246 (ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate) is a 1,8-naphthyridine described to feature an interesting neuroprotective profile in in vitro models of Alzheimer's disease. " 09/18/2013 - "Its potential hepatotoxicity was observed only at very high concentrations, from 0.1 mM. ITH12246, at the concentration of 10 mg/kg i.p., was able to improve the memory index of mice treated with scopolamine, from 0.22 to 0.35, in a similar fashion to the well-known Alzheimer's disease drug galantamine 2.5 mg/kg. On the other hand, ITH12246, at the concentration of 2.5 mg/kg, reduced the phototrombosis-triggered infarct volume by 67%. "

Related Drugs and Biologics

1.	Muscarinic Antagonists
2.	Neuroprotective Agents
3.	Scopolamine (Hyoscine)
4.	Ligands
5.	Galantamine (Galanthamine)