Familial spinal arachnoiditis

A hereditary form of arachnoiditis that may appear as a thick fibrous band on the spinal arachnoid membrane. It is characterized by adult onset SPASTIC PARAPARESIS with prominent radicular pain and patchy numbness. OMIM: 182950

Also Known As:

Networked: 37 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Cysts
2.	Aneurysm (Aneurysms)
3.	Meningeal Tuberculosis (Tuberculous Meningitis)
4.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage)
5.	Arachnoid Cysts (Intracranial Arachnoid Cysts)

Experts

1.	Li, Liang-Ming: 1 article (07/2020)
2.	Shi, Shang-Wen: 1 article (07/2020)
3.	Zheng, Wen-Jian: 1 article (07/2020)
4.	Koeck, Helge: 1 article (11/2019)
5.	Tan, David Chi Hau: 1 article (11/2019)
6.	Vaughan, Kerry A: 1 article (11/2019)
7.	Cuellar, Hugo: 1 article (01/2018)
8.	Dossani, Rimal H: 1 article (01/2018)
9.	Nanda, Anil: 1 article (01/2018)
10.	Patra, Devi P: 1 article (01/2018)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial spinal arachnoiditis:

1.	Hyaluronoglucosaminidase (Hyaluronidase)FDA Link 09/01/1984 - "Because of this therapeutic efficacy and lack of serious toxic effects, intrathecally administered hyaluronidase appears to be of value in the management of spinal arachnoiditis." 03/01/1991 - "Thus this study provides convincing evidence of the therapeutic role of hyaluronidase in the management of tuberculous spinal arachnoiditis and replicates our earlier observation of the safety of hyaluronidase given intrathecally." 03/01/1991 - "Hyaluronidase as an adjuvant in the management of tuberculous spinal arachnoiditis." 09/01/1984 - "Fifteen cases of spinal arachnoiditis of noninfective etiology were treated with intrathecal hyaluronidase. " 09/01/1984 - "Intrathecal hyaluronidase treatment of chronic spinal arachnoiditis of noninfective etiology."
2.	Penicillamine (Cuprimine)FDA Link 02/01/1991 - "Twenty-six patients (13 men and 13 women), ranging in age from 38 to 75 years, with surgical and/or radiculographic evidence of chronic adhesive spinal arachnoiditis (CASA) were admitted to a randomly allocated, double-blind, 6-month crossover trial of d-penicillamine (500 mg/day) versus matching placebo. "
3.	Contrast MediaIBA 06/25/1981 - "[Roentgen contrast media as the cause of spinal arachnoiditis]." 10/01/2006 - "Spinal arachnoiditis can rarely occur following irritation from foreign body substances, including certain oil based contrast agents used for myelography. " 01/01/1978 - "In view of the fact that intrathecal injection both of oily and of water-soluble contrast media tends to produce spinal arachnoiditis, we have been using radionuclides for pre- and postoperative myelography to evaluate arachnoiditis. "
4.	SteroidsIBA 03/01/1991 - "Spinal arachnoiditis, a complication of tuberculous meningitis, is not uncommon; it may develop despite specific chemotherapy and steroids, and existing avenues of treatment for it are unsatisfactory. " 10/01/1997 - "However, in spite of the combination of anti-tuberculous chemotherapy and steroid therapy, her combination of anti-tuberculous chemotherapy and steroid therapy, her consciousness level worsened again in association with paraplegia at the sixth week after admission and magnetic resonance imaging (MRI) revealed multiple tuberculomas, spinal arachnoiditis and spinal cord infarction. "
5.	Iophendylate (Iofendylate)FDA Link 02/01/1963 - "[A case of adhesive spinal arachnoiditis after pantopaque myelography and cisternal myelography with specially devised spinal needles]." 11/01/1985 - "A 62-year-old patient developed severe adhesive spinal arachnoiditis and hydrocephalus with papilledema following iophendylate injection myelography. "
6.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 08/01/2012 - "We present the case of a 58-year-old lady with p-ANCA vasculitis who suffered a WFNS grade 1 subarachnoid haemorrhage (Fisher grade 1) secondary to a ruptured left posterior inferior cerebellar artery aneurysm and then developed a rare complication of radiologically progressive spinal arachnoiditis despite maintained clinical response to definitive treatment measures."
7.	Fibrin Tissue Adhesive (Fibrin Sealant)IBA 03/01/1996 - "The authors urge the readers to keep in mind the possibility of subclinical spinal arachnoiditis in the patients with aneurysmal subarachnoid hemorrhage and suggest that care should be taken to avoid any possible adverse effect of fibrin glue."
8.	Radioisotopes (Radionuclides)IBA 01/01/1978 - "Radionuclide myelography with 131I-HSA or 111In-DTPA is a safe modality which provides useful information regarding spinal arachnoiditis." 01/01/1978 - "The value of radionuclide myelography in the evaluation of spinal arachnoiditis." 01/01/1978 - "In view of the fact that intrathecal injection both of oily and of water-soluble contrast media tends to produce spinal arachnoiditis, we have been using radionuclides for pre- and postoperative myelography to evaluate arachnoiditis. "
9.	Proteins (Proteins, Gene)FDA Link 10/01/2003 - "High cerebrospinal fluid protein appeared to be a risk factor for development of spinal arachnoiditis. "
10.	MetrizamideFDA Link 01/01/1982 - "Two cases showing the features of spinal arachnoiditis on metrizamide myelography were examined by concurrent computed tomography. "

Therapies and Procedures

1.	Spinal Anesthesia 03/01/1955 - "[Spinal arachnoiditis caused by spinal anesthesia; clinical and myelographical study]." 01/01/1957 - "[A case of chronic spinal arachnoiditis with hydromyelia caused by spinal anesthesia]." 07/01/1954 - "Focal spinal arachnoiditis complicating spinal anesthesia."
2.	Anesthesia 04/05/1955 - "[Lumbar anesthesia as a cause of spinal arachnoiditis]." 12/01/1997 - "However, her neurological function deteriorated 4 months after anesthesia and a magnetic resonance imaging (MRI) study revealed spinal arachnoiditis with multiple subarachnoid cysts at the T5-7 levels. "
3.	Therapeutics 10/01/2012 - "Such a history puts them at risk for spinal arachnoiditis, a condition that complicates further ITB therapy. " 09/01/1990 - "The causes, diagnostic features, and therapy of chronic spinal arachnoiditis are reviewed. " 11/01/1964 - "[ON ROENTGEN THERAPY OF SPINAL ARACHNOIDITIS]." 02/01/1962 - "Roentgen therapy in chronic spinal arachnoiditis." 09/01/1986 - "Intrathecal hyaluronidase therapy in tuberculous spinal arachnoiditis."
4.	Epidural Anesthesia 01/01/1994 - "[Spinal arachnoiditis as complication of peridural anesthesia]." 01/01/1993 - "[Spinal arachnoiditis as a complication of peridural anesthesia]." 01/01/1993 - "Seven patients who received epidural anesthesia for gynecological (5 cases), cosmetic (1 case) or general surgery (1 case) developed spinal arachnoiditis leading to subarachnoid cyst in all 7 and cord cavitation in 5. MRI was useful to show the subarachnoid and intramedullary cysts, as well as to monitor lesion extent and progress. " 01/01/1992 - "Three women who received epidural anesthesia for gynecological surgery developed spinal arachnoiditis leading to subarachnoid cysts and cord cavitation. "
5.	Drug Therapy (Chemotherapy) 10/01/1997 - "This is a rare case of progression of spinal arachnoiditis and spinal cord infarction during anti-tuberculous chemotherapy, and who had tuberculoma with a central bright core on MRI." 03/01/1991 - "Spinal arachnoiditis, a complication of tuberculous meningitis, is not uncommon; it may develop despite specific chemotherapy and steroids, and existing avenues of treatment for it are unsatisfactory. " 10/01/1997 - "However, in spite of the combination of anti-tuberculous chemotherapy and steroid therapy, her combination of anti-tuberculous chemotherapy and steroid therapy, her consciousness level worsened again in association with paraplegia at the sixth week after admission and magnetic resonance imaging (MRI) revealed multiple tuberculomas, spinal arachnoiditis and spinal cord infarction. "