2-mercaptopurine

09/01/2011 - "Thiopurine drugs are the most common drugs used to maintain clinical remission in inflammatory bowel disease (IBD). "
01/01/2010 - "The efficacy of thiopurine treatment in the induction, and especially maintenance, of remission in inflammatory bowel disease is well proven; however, it is associated with side effects in both medium and long-term use. "
01/01/2018 - "The review is concluded with suggestions for future work aiming at using a more comprehensive approach to optimize the efficacy of thiopurine compounds in inflammatory bowel disease."
03/01/2015 - "Letter: Thiopurine withdrawal during sustained clinical remission in inflammatory bowel disease."
01/01/2015 - "Editorial: thiopurine withdrawal during sustained clinical remission in inflammatory bowel disease."

07/01/2015 - "Thiopurine use might be beneficial for the long-term maintenance of remission in biologic-naive Crohn's disease patients without digestive complications and a history of surgery."
12/01/2011 - "Thiopurine agents have been shown to be effective in maintaining remission in patients with Crohn's disease. "
11/01/2020 - "The results of this study may help clinicians to understand the effects of other various polymorphisms in addition to TPMT and NUDP15 in thiopurine metabolism for management of Crohn's disease patients."
11/01/2020 - "This study explores the effects of various genetic polymorphisms in candidate genes on thiopurine metabolism and toxicity in adult patients with Crohn's disease in Korea. "
11/01/2016 - "A recent study identified a variant of the NUDT15 gene (rs116855232 C>T) associated with intolerance to thiopurine in Korean patients with Crohn's disease. "

07/01/2015 - "The long-term clinical outcomes of patients with bio-naive ulcerative colitis (UC) who maintain remission with thiopurine are unclear. "
01/01/2018 - "Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study."
05/01/2011 - "Outcome following thiopurine use in children with ulcerative colitis: a prospective multicenter registry study."
10/16/2020 - "Thiopurine Drugs in the Treatment of Ulcerative Colitis: Identification of a Novel Deleterious Mutation in TPMT."
11/01/2018 - "Or aim was to determine the outcome of thiopurine application in children diagnosed with ulcerative colitis (UC). "

06/01/1993 - "Levels of TPMT activity in human tissue are controlled by a common genetic polymorphism that is an important factor responsible for individual variation in thiopurine drug toxicity and therapeutic efficacy. "
01/01/2010 - "This study demonstrated significant variations in TPMT gene polymorphisms in an Indian population in relation to other human populations and may help to predict both clinical efficacy and drug toxicity of thiopurine drugs."
10/01/2008 - "TPMT is genetically polymorphic and is associated with large interindividual variations in thiopurine drug toxicity and therapeutic efficacy. "
02/01/2005 - "TPMT is genetically polymorphic and is associated with large interindividual variations in thiopurine drug toxicity and therapeutic efficacy. "
09/01/2003 - "A common genetic polymorphism for TPMT is associated with large individual variations in thiopurine drug toxicity and therapeutic efficacy. "

01/01/2023 - "In this study, we evaluated TaqMan PCR for detection of the NUDT15 single-nucleotide polymorphisms (SNPs) and examined the clinical impact of Arg139His on thiopurine-induced leukopenia. "
01/01/2020 - "Recent large-scale clinical studies revealed a strong association between the NUDT15 p.Arg139Cys (NUDT15R139C) polymorphism and severe thiopurine-induced leukocytopenia. "
01/01/2019 - "MEDLINE, EMBASE, BIOSIS and Cochrane library were searched for studies reporting at least one risk factor for thiopurine-induced leukopenia. "
01/01/2018 - "Despite several studies being conducted to examine the associations between the NUDT15 R139C polymorphism and thiopurine-induced leukopenia in the Asian population, the results remain inconsistent. "
01/01/2018 - "We herein conducted a systematic review and meta-analysis of published studies to estimate diagnostic accuracy of NUDT15 gene polymorphisms for detection of thiopurine-induced leukopenia. "