p-coumaric acid

from the ethyl acetate extract of Drimia robusta

Also Known As:

4-coumaric acid; 4-coumaric acid, (E)-isomer; 4-coumaric acid, (Z)-isomer; 4-coumaric acid, disodium salt; 4-hydroxycinnamic acid; p-coumaryl alcohol; p-hydroxycinnamic acid; para-coumaric acid; phenol, 4-(3-hydroxy-1-propenyl)-; trans-3-(4'-hydroxyphenyl)-2-propenoic acid; trans-HPPA

Networked: 186 relevant articles (20 outcomes, 39 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Cinnamates: 48
      - Coumaric Acids: 128
        p-coumaric acid: 186

Experts

1.	Yamaguchi, Masayoshi: 10 articles (02/2021 - 11/2006)
2.	Rasool, Mahaboobkhan: 6 articles (12/2018 - 08/2012)
3.	Murata, Tomiyasu: 4 articles (02/2021 - 10/2015)
4.	Mard, Seyyed Ali: 4 articles (05/2020 - 08/2019)
5.	Pragasam, Samuel Joshua: 4 articles (05/2013 - 08/2012)
6.	Lai, Ying Ling: 4 articles (09/2008 - 11/2006)
7.	Gál, Miroslav: 3 articles (03/2020 - 10/2019)
8.	Kotyńska, Joanna: 3 articles (03/2020 - 10/2019)
9.	Kruszewski, Marcin Andrzej: 3 articles (03/2020 - 10/2019)
10.	Kusaczuk, Magdalena: 3 articles (03/2020 - 10/2019)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2022 - "Thus p-coumaric acid ameliorates the FPN induced liver injury in mice through attenuation of structural changes, oxidative stress, and inflammation." 11/01/2004 - "Plant phenolic 4-coumaric acid protects against intestinal inflammation in rats." 11/01/2022 - "p-Coumaric acid ameliorates cognitive and non-cognitive disturbances in a rat model of Alzheimer's disease: The role of oxidative stress and inflammation." 01/01/2022 - "dracunculifolia (HEBD) and its major compound p-coumaric acid were evaluated against the severity of intestinal inflammation and behavioral changes like depressive and anxious behavior in colitis mice. " 01/01/2022 - "P-coumaric acid ameliorates fipronil induced liver injury in mice through attenuation of structural changes, oxidative stress and inflammation."
2.	Obesity 01/01/2020 - "p-Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1-RPS6." 06/21/2021 - "Peanut sprout rich in p-coumaric acid ameliorates obesity and lipopolysaccharide-induced inflammation and the inhibition of browning in adipocytes via mitochondrial activation." 09/01/2019 - "Inhibition of adipogenesis was shown to be 14.0±1.85% for betaine chloride and 38.3±3.27% for p-coumaric acid, suggesting that p-coumaric acid is more effective than betaine against obesity. " 10/01/2021 - "p-Coumaric acid (PC), a naturally occurring phytochemical, possesses antioxidant and anti-inflammatory properties; however, the mechanisms underlying its protective effects against obesity-related metabolic dysfunction are largely unknown. " 01/01/2023 - "Combination therapy of metformin and p-coumaric acid mitigates metabolic dysfunction associated with obesity and nonalcoholic fatty liver disease in high-fat diet obese C57BL/6 mice."
3.	Cardiotoxicity 07/01/2011 - "This study is based on the possible protective effects of combination of p-coumaric acid (PC) and naringenin (NR) on DOX induced cardiac toxicity in male Swiss albino rats. " 01/01/2023 - "Protective Effect of Quercetin and p-Coumaric Acid (p-CA) Against Cardiotoxicity: An In Silico Study." 04/01/2014 - "In conclusion, this study confirmed that p-coumaric acid could be a promising dietary agent for protecting against the sodium arsenite-induced cardiotoxicity. " 05/01/2013 - "This study was performed to investigate the ameliorative role of p-coumaric acid against sodium arsenite-induced cardiotoxicity in rats. " 06/01/2018 - "p-Coumaric acid mediated protection of H9c2 cells from Doxorubicin-induced cardiotoxicity: Involvement of augmented Nrf2 and autophagy."
4.	Hypoxia (Hypoxemia) 10/15/2018 - "Previous studies indicate that the anti-hypoxia effects of Tibetan Turnip (Brassica rapa ssp. rapa) were closely related to its characteristic components being p-coumaric acid (CA) and p-coumaric acid‑β‑d‑glucopyranoside (CAG). " 05/01/2016 - "In this study, we report p-coumaric acid as novel and effective response marker for indirectly measuring the levels of hypoxia in normal primary bronchial epithelial cells. " 10/15/2018 - "p-Coumaric acid as a prophylactic measure against normobaric hypoxia induced pulmonary edema in mice." 05/01/2016 - "We interpret the increasing p-coumaric acid concentrations during hypoxia as a result of cell damage, triggered by reduced co-enzyme Q10 levels, because the oxidative cascade was not able to supply sufficient energy. " 05/01/2016 - "During 168h of hypoxia without induction of reactive oxygen species (ROS), an almost linear increase of p-coumaric acid levels was observed. "
5.	Melanoma (Melanoma, Malignant) 01/12/2023 - "Previous studies reported that p-coumaric acid modulates melanoma growth. " 11/19/2023 - "A nano-liposomal carrier containing p-coumaric acid for induction of targeted apoptosis on melanoma cells and kinetic modeling." 01/12/2023 - "Esterification of p-Coumaric Acid Improves the Control over Melanoma Cell Growth." 03/01/2015 - "The results indicate that the addition of methoxy groups to p-coumaric acid shows the melanogenic or cytotoxic effects in melanoma cells compared to the original compound. " 01/01/2020 - "Low-level laser irradiation potentiates anticancer activity of p-coumaric acid against human malignant melanoma cells."

Related Drugs and Biologics

1.	Antioxidants
2.	caffeic acid
3.	ferulic acid (sodium ferulate)
4.	Acids
5.	Polyphenols
6.	Lipopolysaccharides
7.	Gallic Acid
8.	Esters
9.	Glucose (Dextrose)
10.	naringenin

Related Therapies and Procedures

1.	Chemoprevention
2.	Therapeutics
3.	Lasers (Laser)
4.	Intravenous Injections
5.	Oral Administration