pterocellin A

alkaloids from the marine bryozoan Pterocella vesiculosa; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Melanoma (Melanoma, Malignant) 01/01/2016 - "It exhibits potent antitumour activity towards the P388 (murine leukaemia) cell line in vitro and is selectively sensitive towards certain non-small cell lung, melanoma, and breast cancer cell lines, however, the biological mode of action of pterocellin A is unknown. "
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 01/01/2016 - "Using the human cervical cancer cell line HeLa, we show that pterocellin A exhibited cytotoxicity against HeLa cells with an IC50 of 886 ng/mL. Time-course MTT and LDH assays were carried out and the results showed only a low level of cytosolic LDH was detected in the supernatant after all the cells have died from pterocellin A treatment at 2000 ng/mL. This indicated the cells maintained membrane integrity upon cell death which suggested apoptotic cell death. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2016 - "It exhibits potent antitumour activity towards the P388 (murine leukaemia) cell line in vitro and is selectively sensitive towards certain non-small cell lung, melanoma, and breast cancer cell lines, however, the biological mode of action of pterocellin A is unknown. "