LL Z1640-2

structure in first source

Also Known As:

8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,9,10-tetrahydro-1H-benzo(c)(1)oxacyclotetradecine-1,7(8H)-dione; FR 148083; FR-148083; FR148083; LL-Z1640-2; f152A1 compound

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Lactones: 1549
  - LL Z1640-2: 3

Experts

1.	Abe, Masahiro: 1 article (01/2022)
2.	Ashtar, Mohannad: 1 article (01/2022)
3.	Endo, Itsuro: 1 article (01/2022)
4.	Hara, Tomoyo: 1 article (01/2022)
5.	Harada, Takeshi: 1 article (01/2022)
6.	Hiasa, Masahiro: 1 article (01/2022)
7.	Higa, Yoshiki: 1 article (01/2022)
8.	Inoue, Yusuke: 1 article (01/2022)
9.	Maruhashi, Tomoko: 1 article (01/2022)
10.	Matsumoto, Toshio: 1 article (01/2022)

Related Diseases

1.	Lymphoma (Lymphomas) 08/01/2023 - "Therapeutic efficacy of the resorcylic acid lactone LL-Z1640-2 for adult T-cell leukaemia/lymphoma."
2.	Inflammation (Inflammations) 01/01/2022 - "Here, we explored the efficacy of the potent TGF-β-activated kinase-1 (TAK1) inhibitor LL-Z1640-2 (LLZ) on joint inflammation and bone destruction in collagen-induced arthritis (CIA). " 01/01/2022 - "TGF-β-activated kinase-1 inhibitor LL-Z1640-2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF-α and RANKL expression."
3.	Experimental Arthritis 01/01/2022 - "Here, we explored the efficacy of the potent TGF-β-activated kinase-1 (TAK1) inhibitor LL-Z1640-2 (LLZ) on joint inflammation and bone destruction in collagen-induced arthritis (CIA). "
4.	Cholangiocarcinoma 11/01/2022 - "LL-Z1640-2 and patulin also induced apoptosis in BRAF inhibitor-resistant melanoma, pancreatic cancer, cholangiocarcinoma and colorectal cancer cells. "
5.	Colorectal Neoplasms (Colorectal Cancer) 11/01/2022 - "LL-Z1640-2 and patulin also induced apoptosis in BRAF inhibitor-resistant melanoma, pancreatic cancer, cholangiocarcinoma and colorectal cancer cells. "

Related Drugs and Biologics

1.	Lactones
2.	Acids
3.	Inflammasomes
4.	Proteins (Proteins, Gene)
5.	Patulin