JL1 antigen

a thymocyte-differentiation antigen of MW 120 kDa, present in leukemia patients but not in normal individuals; specific target for diagnosis & treatment of leukemia

Also Known As:

antigen JL1

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Biomarkers: 240291
  - Differentiation Antigens: 2082
    - T-Lymphocyte Differentiation Antigens: 40
      - JL1 antigen: 5
- Antigens: 143924
  - Surface Antigens: 5813
    - Differentiation Antigens: 2082
      - T-Lymphocyte Differentiation Antigens: 40
        JL1 antigen: 5

Experts

1.	Park, S H: 2 articles (05/2001 - 04/2001)
2.	Cho, Young Uk: 1 article (01/2020)
3.	Huh, Jooryung: 1 article (01/2020)
4.	Im, Ho Joon: 1 article (01/2020)
5.	Jang, Seongsoo: 1 article (01/2020)
6.	Kim, Min Sun: 1 article (01/2020)
7.	Park, Chan Jeoung: 1 article (01/2020)
8.	Park, Chan Sik: 1 article (01/2020)
9.	Seo, Eul Ju: 1 article (01/2020)
10.	Seo, Jong Jin: 1 article (01/2020)

Related Diseases

1.	Leukemia 04/01/2001 - "Expression of leukemia-associated antigen, JL1, in bone marrow and thymus." 10/01/1998 - "Since the JL1 antigen is selectively expressed on the surface of human leukemic cells but not on the mature human peripheral blood cells, normal bone marrow cells and various types of normal tissues, JL1 could be an excellent candidate for an immunodiagnostic and immunotherapeutic tool for hematopoietic malignancies such as leukemia." 05/14/2001 - "Anti-JL1 antibody has been proven to bind to JL1 antigen and subsequently be internalized into Molt 4 cells, demonstrating that anti-JL1 antibody has the potential as a targeting ligand for leukemia-specific gene transfer. " 05/14/2001 - "We have designed the gene delivery carrier targeted to Molt 4 cells, human leukemia T cells, using monoclonal antibody against leukemia-specific JL1 antigen, anti-JL1 antibody, as a targeting moiety. " 10/01/1998 - "Since JL1 antigen is selectively expressed on the surface of human leukemic cells, but not on mature human peripheral blood cells and normal bone marrow cells, anti-JL1 mAb can be used as a reagent of choice in the routine diagnosis of various types of leukemia, providing an excellent candidate for the treatment of these diseases."
2.	Hematologic Neoplasms (Hematological Malignancy) 10/01/1998 - "Since the JL1 antigen is selectively expressed on the surface of human leukemic cells but not on the mature human peripheral blood cells, normal bone marrow cells and various types of normal tissues, JL1 could be an excellent candidate for an immunodiagnostic and immunotherapeutic tool for hematopoietic malignancies such as leukemia."
3.	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/01/2020 - "JL1 Antigen Expression on Bone Marrow Lymphoma Cells from Patients With Non-Hodgkin Lymphoma."
4.	Lymphoma (Lymphomas) 01/01/2020 - "JL1 Antigen Expression on Bone Marrow Lymphoma Cells from Patients With Non-Hodgkin Lymphoma."

Related Drugs and Biologics

1.	Ligands
2.	Indicators and Reagents (Reagents)
3.	Monoclonal Antibodies