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LY 306089
testosterone 5-alpha-reductase antagonist; structure given in first source
Also Known As:
8,9-dichloro-4,10b-dimethyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)quinolin-3-one; LY306089
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Quinones: 434
Benzoquinones: 25
LY 306089: 1
Related Diseases
1.
Castration-Resistant Prostatic Neoplasms
05/01/1996 - "
LY306089 was a non-competitive inhibitor of type I 5 alpha-reductase in DU145 cellular homogenates with an apparent Ki value of 4.0 nM. These studies have identified and pharmacologically defined type I 5 alpha-reductase activity in an androgen-insensitive prostatic cancer cell line and provide the basis for additional investigations into the significance of type I 5 alpha-reductase to human prostatic pathophysiology.
"
Related Drugs and Biologics
1.
Cholestenone 5 alpha-Reductase (5 alpha-Reductase)