HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
CX 397
a recombinant hirudin analog; a specific thrombin inhibitor
Also Known As:
CX-397
Networked:
3
relevant articles (
2
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Recombinant Proteins: 2754
CX 397: 3
Serpins: 906
Antithrombin Proteins: 6
Hirudins: 707
CX 397: 3
Peptides: 82426
Serpins: 906
Antithrombin Proteins: 6
Hirudins: 707
CX 397: 3
Related Diseases
1.
Thrombosis (Thrombus)
02/01/1998 - "
All saline-treated control animals (7/7) developed thrombotic occlusion during the experimental period, leaving a residual thrombus mass of 15.4 +/- 3.8 mg. Treatment with CX-397 at three incremental dose levels reduced the incidence of occlusion (4/7, 2/5 and 0/7) and decreased thrombus weight (12.6 +/- 2.5 mg, 6.3 +/- 3.0 mg and 2.1 +/- 1.3 mg, respectively) in a dose-dependent manner.
"
02/01/1999 - "
The hemorrhagic risk of CX-397 in template bleeding in rats was not higher than that of rHV-1, indicating that CX-397 is superior to rHV-1 for treating the platelet-dominant type of thrombosis.
"
02/01/1998 - "
We conducted a comparative study of CX-397 and heparin in a canine model of left circumflex (LCX) coronary artery thrombosis to evaluate the anti-thrombotic efficacy of CX-397.
"
02/01/1998 - "
In conclusion, CX-397 dose-dependently suppressed thrombus formation by inhibition of thrombin activity in a canine coronary artery injury model.
"
02/01/1998 - "
Anti-thrombotic effects of CX-397, a recombinant hirudin analog, in a canine model of coronary artery thrombosis.
"
2.
Hemorrhage
02/01/1999 - "
The hemorrhagic risk of CX-397 in template bleeding in rats was not higher than that of rHV-1, indicating that CX-397 is superior to rHV-1 for treating the platelet-dominant type of thrombosis.
"
Related Drugs and Biologics
1.
Heparin (Liquaemin)
2.
Thrombin
3.
Hirudins
4.
ferric chloride