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lysyl- tyrosyl- glycyl- cysteinyl- homoarginyl- glycyl- aspartyl- tryptophyl- prolyl- cysteine cyclic (4-10)-disulfide

cHarGD - cyclic homoarginine-glycine-aspartic acid-containing peptide; ligand for platelet membrane glycoprotein IIb-IIIa

Also Known As:

KYGC(s-s)HarGDWPC(s-s); cHarGD

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - lysyl-tyrosyl-glycyl-cysteinyl-homoarginyl-glycyl-aspartyl-tryptophyl-prolyl-cysteine cyclic (4-10)-disulfide: 1
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - lysyl-tyrosyl-glycyl-cysteinyl-homoarginyl-glycyl-aspartyl-tryptophyl-prolyl-cysteine cyclic (4-10)-disulfide: 1

Experts

1.	Dutta, Samrat: 1 article (01/2013)
2.	Guthold, Martin: 1 article (01/2013)
3.	Hantgan, Roy R: 1 article (01/2013)
4.	Horita, David A: 1 article (01/2013)

Related Diseases

1.

01/01/2013 - "Analysis of αIIbβ3:cHarGD DFS rupture force data at pulling rates of 14 000 pN/s, 42 000 pN/s and 70 000 pN/s yielded koff = 0.02-0.09 s-1, a dissociation energy barrier [Formula: see text] = 22-29 kJ/mol, and a potential well width x-1 = 0.5-0.8 nm. SPR kinetic data yielded an association rate constant kon = 7 × 103 L/mol-s and a dissociation rate constant koff = 10-2 s-1, followed by a slower stabilization step (τ ~ 400 s). "