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SDZ ICT 322
structure given in first source
Also Known As:
SDZ-ICT-322; indole-3-carboxyl acid 9-methyl-3-oxa-9-azatricyclo(3.3.1.0(2,4))non-7-yl ester; 1H-Indole-3-carboxylic acid, 9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester, (1alpha,2beta,4beta,5alpha,7beta)-
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
SDZ ICT 322: 2
Related Diseases
1.
Cataract (Cataracts)
01/01/1997 - "
In SDZ ICT 322 treated VE/SeD rats cataracts were observed by week 7, whereas in rats fed normal diet cataracts were first seen in week 14.
"
01/01/1997 - "
In the normal dietary group no corneal opacity was found after SDZ ICT 322-treatment; however, a corneal opacity was seen in the deficiency group in parallel with one of the cataract animals in week 7. The incidence and severity of clinical skin signs were greater and their onset was earlier in the deficiency dietary group: onset occurred after 6 weeks compared to 9 weeks on the normal diet.
"
01/01/1997 - "
SDZ ICT 322, is a selective hydroxytryptamine (5-HT3) antagonist, which after chronic treatment causes posterior subcapsular cataracts and skin changes such as hair loss, hyperaemia, desquamation and hyperkeratosis in rats.
"
10/01/1993 - "
Since decreased GSH/GSSG ratio is an established indicator for increased oxygen radical generation, these data suggest a possible role of oxidative stress in cataracts induced by SDZ ICT 322.
"
2.
Corneal Opacity
01/01/1997 - "
In the normal dietary group no corneal opacity was found after SDZ ICT 322-treatment; however, a corneal opacity was seen in the deficiency group in parallel with one of the cataract animals in week 7. The incidence and severity of clinical skin signs were greater and their onset was earlier in the deficiency dietary group: onset occurred after 6 weeks compared to 9 weeks on the normal diet.
"
3.
Alopecia (Baldness)
01/01/1997 - "
SDZ ICT 322, is a selective hydroxytryptamine (5-HT3) antagonist, which after chronic treatment causes posterior subcapsular cataracts and skin changes such as hair loss, hyperaemia, desquamation and hyperkeratosis in rats.
"
Related Drugs and Biologics
1.
Glutathione Disulfide (GSSG)
2.
Reactive Oxygen Species (Oxygen Radicals)
3.
Serotonin (5 Hydroxytryptamine)
4.
Indicators and Reagents (Reagents)