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dynorphin (2-17)
does not have opioid binding potential
Also Known As:
(des-Tyr(1))dyn A; 1-de-Tyr-dynorphin; 1-de-tyrosine-dynorphin; 1-desTyr-dynorphin A; dyn A (2-17); dynorphin A (2-17); dynorphin A, desTyr(1)-; dynorphin A, destyrosyl(1)-; dynorphin, des-Tyr(1)-; dynorphin, des-tyrosine(1)-
Networked:
4
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Proteins: 484843
Nerve Tissue Proteins: 2
Neuropeptides: 6772
Opioid Peptides: 1339
Dynorphins: 819
dynorphin (2-17): 4
Peptides: 82426
Neuropeptides: 6772
Opioid Peptides: 1339
Dynorphins: 819
dynorphin (2-17): 4
Peptide Fragments: 373
dynorphin (2-17): 4
Related Diseases
1.
Paralysis (Palsy)
01/15/1990 - "
In the present studies we examined whether competitive [(4-[3-phosphonopropyl]-2-piperazine-carboxylic acid (CPP)] or non-competitive (dextrorphan) NMDA antagonists could attenuate paralysis induced by Dyn A(1-17) or Dyn A(2-17).
"
2.
Neurologic Manifestations (Neurological Manifestations)
01/15/1990 - "
In addition, CPP and dextrorphan significantly reduced the neurologic dysfunction caused by Dyn A(2-17)(all P less than 0.05).
"
3.
Hypothermia
07/01/1989 - "
Interestingly, des-Tyr-Dynorphin A (Dyn A-(2-17)), a fragment with virtually no opioid binding potential, was 4 times less potent that Dyn A in inducing hypothermia.
"
4.
Hyperalgesia
08/01/1997 - "
Similarly, dynorphin A (2-17) (3 nmol, i.t.), a non-opioid peptide, induced cold and tactile allodynia analogous to that induced by dynorphin A (1-17), indicating the importance of non-opioid receptors.
"
5.
Hemorrhage
06/04/1993 - "
With the exception of the first 10 min post-hemorrhage, where intracerebral injection of both dynorphin 1-17 and dynorphin 2-17 caused a transient suppression of mean arterial blood pressure (P < 0.05 when compared to saline-treated controls), microinjection of the kappa-agonists dynorphin 1-17 or U-50,488H had no effect on blood pressure, heart rate or mortality when compared to control animals.
"
06/04/1993 - "
15 min prior to fixed volume hemorrhage (7.5 ml/300 g), male Sprague-Dawley rats (n = 59) received a microinjection of either (1) the synthetic kappa-receptor agonist U-50,488H (10 nM) or (2) U-50,488H (100 nM) or (3) the endogenous kappa-receptor agonist dynorphin 1-17 (1 nM) or (4) Des-Tyr dynorphin 2-17, inactive at opiate receptors (1 nM) or (5) equal volume saline.
"
Related Drugs and Biologics
1.
N-Methylaspartate (NMDA)
2.
Dextrorphan
3.
Carboxylic Acids
4.
Piperazine
5.
6-chloro-2-(1-piperazinyl)pyrazine (CPP)
6.
Dynorphins (Dynorphin)
7.
Opioid Receptors (Opioid Receptor)
8.
(trans)-Isomer 3,4- Dichloro- N- methyl- N- (2- (1- pyrrolidinyl)- cyclohexyl)- benzeneacetamide
9.
Opioid Peptides (Opioid Peptide)
10.
kappa Opioid Receptors (kappa Opioid Receptor)