HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
polyoxyethylene-superoxide dismutase
recombinant human Cu,Zn superoxide dismutase with polyoxyethylene; decreases side effects of superoxide-generating antineoplastics such as adriamycin and mitomycin C
Also Known As:
POE-SOD; SOD-POE; polyoxyethylene-modified superoxide dismutase
Networked:
4
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Alcohols: 595
Glycols: 38
Ethylene Glycols: 8
Polyethylene Glycols: 3865
polyoxyethylene-superoxide dismutase: 4
Macromolecular Substances: 97
Polymers: 13051
Polyethylene Glycols: 3865
polyoxyethylene-superoxide dismutase: 4
Biomedical and Dental Materials
Polymers: 13051
Polyethylene Glycols: 3865
polyoxyethylene-superoxide dismutase: 4
Technology, Industry, and Agriculture
Manufactured Materials
Biomedical and Dental Materials
Polymers: 13051
Polyethylene Glycols: 3865
polyoxyethylene-superoxide dismutase: 4
Enzymes and Coenzymes: 1
Enzymes: 152586
Oxidoreductases: 13671
Superoxide Dismutase: 11100
polyoxyethylene-superoxide dismutase: 4
Related Diseases
1.
Ischemia
05/01/1993 - "
Although SOD-POE did not affect the decrease of ATP during ischemia, it improved significantly the recovery of ATP: 28%.
"
09/01/1991 - "
This study was designed to clarify the mechanism of ischemia-reperfusion-induced rat liver injury and to evaluate the effect of long-acting superoxide dismutase (SOD-POE).
"
05/01/1993 - "
SOD-POE did not affect xanthine oxidase activity during ischemia and reperfusion.
"
05/01/1993 - "
SOD-POE did not affect LPO levels during ischemia but prevented the increase of LPO significantly after reperfusion (0.98 +/- 0.25 nmol/mg protein).
"
09/01/1991 - "
SOD-POE did not affect the decrease in ATP levels or the increase in purine nucleotide levels during ischemia.
"
2.
Reperfusion Injury
05/01/1993 - "
This study was designed to clarify the mechanism of ischemia-reperfusion injury to skeletal muscle using long-acting polyoxyethylene-modified superoxide dismutase (SOD-POE) in rats.
"
05/01/1993 - "
These results suggest that lipid peroxidation by superoxide radicals produced by xanthine oxidase is a contributory factor to ischemia-reperfusion injury to skeletal muscle, and the clinical application of SOD-POE might be expected.
"
3.
Coronary Stenosis (Coronary Artery Stenosis)
10/01/1990 - "
Effect of polyoxyethylene-modified superoxide dismutase on recovery of myocardial dysfunction after coronary stenosis in dogs.
"
10/01/1990 - "
The effects of superoxide dismutase modified with polyoxyethylene (SOD-POE) on impairment of myocardial segment shortening (SS) during coronary stenosis plus pacing-induced tachycardia (CSPT) and the recovery after reperfusion was examined in anesthetized dogs.
"
4.
Atrial Premature Complexes (Premature Atrial Contraction)
05/01/1989 - "
In the control group (rat hearts), arrhythmias including ventricular fibrillation (Vf) (incidence, 64.3 to 83.3%), ventricular tachycardia (VT) (66.7 to 84.6%), premature ventricular contraction (PVC) and premature atrial contraction (PAC) occurred immediately after reperfusion and lasted for 1 to 3 min. In both groups treated with SOD-POE (10 U/ml) or native human SOD (10 U/ml), the incidence of Vf and VT was 0% and the number of PVCs significantly decreased.
"
5.
Ventricular Premature Complexes (Premature Ventricular Contraction)
05/01/1989 - "
In the control group (rat hearts), arrhythmias including ventricular fibrillation (Vf) (incidence, 64.3 to 83.3%), ventricular tachycardia (VT) (66.7 to 84.6%), premature ventricular contraction (PVC) and premature atrial contraction (PAC) occurred immediately after reperfusion and lasted for 1 to 3 min. In both groups treated with SOD-POE (10 U/ml) or native human SOD (10 U/ml), the incidence of Vf and VT was 0% and the number of PVCs significantly decreased.
"
Related Drugs and Biologics
1.
Adenosine Triphosphate (ATP)
2.
polyoxyethylene-superoxide dismutase
3.
Superoxide Dismutase
4.
Xanthine Oxidase
5.
Superoxides (Superoxide)
6.
Proteins (Proteins, Gene)
7.
Polyvinyl Chloride (PVC)
8.
Polyethylene Glycols (Polyethylene Glycol)
9.
Nucleotides
10.
purine