philanthotoxin 343

structure given in first source (see article's footnote); identical to philanthotoxin 433 except that the number of methylene groups between the respective amine moieties is 3,4,3 instead of 4,3,3

Also Known As:

PHTX 343; PHTX-343; philanthotoxin-343; Benzenepropanamide, N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-4-hydroxy-alpha-((1-oxobutyl)amino)-, (S)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - philanthotoxin 343: 2
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        philanthotoxin 343: 2

Experts

1.	Abu, Izuddin Fahmy: 2 articles (01/2021 - 01/2020)
2.	Agarwal, Renu: 2 articles (01/2021 - 01/2020)
3.	Fazel, Muhammad Fattah: 2 articles (01/2021 - 01/2020)
4.	Franzyk, Henrik: 2 articles (01/2021 - 01/2020)
5.	Iezhitsa, Igor: 2 articles (01/2021 - 01/2020)
6.	Juliana, Norsham: 2 articles (01/2021 - 01/2020)
7.	Mellor, Ian R: 2 articles (01/2021 - 01/2020)
8.	Mohamad, Mohamad Haiqal Nizar: 2 articles (01/2021 - 01/2020)
9.	Bakar, Nor Salmah: 1 article (01/2020)

Related Diseases

1.	Vision Disorders (Hemeralopia) 01/01/2021 - "In conclusion, PhTX-343 pretreatment protects against NMDA-induced retinal morphological changes and visual impairment by suppressing nitrosative stress as reflected by the reduced retinal 3-NT level." 01/01/2020 - "These findings suggested that PhTX-343 inhibit retinal cell loss, optic nerve damage, and visual impairments in NMDA-induced rats."
2.	Ganglion Cysts (Ganglion) 01/01/2021 - "Morphological examination of retinal tissues showed that the fractional ganglion cell layer thickness within the inner retina (IR) in the PhTX-343 treated group was greater by 1.28-fold as compared to NMDA-treated rats (p < 0.05) and was comparable to control rats (p > 0.05). "
3.	Optic Nerve Injuries 01/01/2020 - "Philanthotoxin-343 attenuates retinal and optic nerve injury, and protects visual function in rats with N-methyl-D-aspartate-induced excitotoxicity."

Related Drugs and Biologics

1.	N-Methylaspartate (NMDA)
2.	Retinaldehyde (Retinal)