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3- (cis- 2,6- dimethylpiperidino)sydnonimine
structure given in first source; an exogenous source of nitric oxide
Also Known As:
C 3754; C 87-3754; C-3754; C-87-3754; C87-3754; CAS-754; Sydnone imine, 3-(2,6-dimethyl-1-piperidinyl)-, cis-
Networked:
5
relevant articles (
2
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Azoles: 2138
Oxazoles: 89
Oxadiazoles: 146
Sydnones: 2
3-(cis-2,6-dimethylpiperidino)sydnonimine: 5
Related Diseases
1.
Shock
01/01/1993 - "
In the first case, C87-3754, but not C88-3934, attenuated myocardial necrosis, and in the second case, the NO donor improved survival and moderated the indices of shock.
"
11/01/1992 - "
Moreover, C87-3754 attenuated the SAO shock induced decline in release of endothelium-derived relaxing factor (EDRF) from isolated superior mesenteric artery (SMA) rings stimulated by acetylcholine and A23187.
"
2.
Ventricular Fibrillation
04/01/1997 - "
The nitric oxide donor C87-3754 (1 mg/kg) caused a significant reduction in arterial blood pressure before coronary artery ligation but did not influence the incidence or severity of ventricular arrhythmias during a 30-min period of myocardial ischaemia [60 and 58% incidence of ventricular fibrillation (VF) in control and treated rats, respectively].
"
3.
Necrosis
01/01/1993 - "
In the first case, C87-3754, but not C88-3934, attenuated myocardial necrosis, and in the second case, the NO donor improved survival and moderated the indices of shock.
"
4.
Myocardial Ischemia (Ischemic Heart Diseases)
02/01/1992 - "
Our studies show that SIN-1 and C87-3754 exert beneficial effects in a 6-h model of myocardial ischemia-reperfusion.
"
5.
Leukopenia
09/01/1996 - "
Administration of the NO donor C87-3754 (0.75 mg kg-1 h-1, beginning 1 min after the onset of reperfusion) slightly increased survival time and reduced MPO activity and leukopenia, but did not change survival rate and mean arterial blood pressure.
"
09/01/1996 - "
In fact, co-administration of Ethyl-TU plus C87-3754 completely prevented mortality, reduced MPO activity, attenuated leukopenia and the profound hypotension and restored the impaired responsiveness of aortic rings to PE and ACh.
"
Related Drugs and Biologics
1.
Nitric Oxide Donors
2.
Endothelium-Dependent Relaxing Factors (Endothelium Derived Relaxing Factor)
3.
Acetylcholine (Acetylcholine Chloride)
4.
Calcimycin (A23187)
Related Therapies and Procedures
1.
Ligation