N- (9H- (2,7- dimethylfluoren- 9- ylmethoxy)carbonyl)leucine
RN given refers to the (L-Leu)-isomer
Also Known As:
NPC 15669; NPC-15669
Networked: 21
relevant articles (4 outcomes,
2 trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Related Diseases
1. | Colitis
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2. | Inflammation (Inflammations)
04/01/1993
- " Intrarectal pretreatment with NPC 15669 results in a significant reduction of all measured indices of inflammation. " 05/25/1993
- " Effect of NPC 15669, an inhibitor of neutrophil recruitment and neutrophil-mediated inflammation, on neutrophil function in vitro." 07/15/1994
- " Finally, the leumedin NPC 15669, which had previously been shown to inhibit stimulated CD11b expression and neutrophil adherence to endothelial cells and to exhibit anti-inflammatory properties in various in vivo models of inflammation, inhibited the stimulation of tyrosine, phosphorylation induced by fMet-Leu-Phe. " 05/25/1993
- " The new anti-inflammatory agent N-[9H-(2,7-dimethylfluorenyl-9-methoxy)carbonyl]-L-leucine (NPC 15669) inhibits inflammation in several animal models dependent upon neutrophil activation and recruitment into the inflammatory lesion. " 03/01/1992
- " NPC 15669, a member of a new class of antiinflammatory agents termed leumedins, blocks inflammation in several animal models, including contact dermatitis and Arthus reaction, by inhibiting recruitment of neutrophils and lymphocytes into inflammatory lesions. "
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3. | Myocardial Infarction
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4. | Leukopenia
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5. | Myocardial Stunning (Stunned Myocardium)
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Related Drugs and Biologics
Related Therapies and Procedures