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Bay R 1531
serotonin-1a receptor agonist
Also Known As:
Bay R-1531; Benz(cd)indol-4-amine, 1,3,4,5-tetrahydro-6-methoxy-N,N-dipropyl-, monohydrochloride
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Bay R 1531: 3
Related Diseases
1.
Ischemia
12/01/1990 - "
We tested the full agonists Bay R 1531 and 8-OH-DPAT and the partial agonists ipsapirone and gepirone in the model of transient global ischemia in the Mongolian gerbil.
"
12/01/1990 - "
Drugs were applied 30 minutes before the induction of ischemia, and efficacy was demonstrated for 8-OH-DPAT (1 mg/kg s.c.), buspirone (10 mg/kg i.p.), gepirone (10 mg/kg i.p.), ipsapirone (10 or 30 mg/kg i.p.), and Bay R 1531 (1 mg/kg i.p.).
"
2.
Infarction (Infarctions)
12/01/1990 - "
The most pronounced effects were seen with the higher dose of ipsapirone and Bay R 1531, both compounds reducing cortical infarct size by more than 60%.
"
3.
Bites and Stings (Sting)
03/26/1998 - "
The full 5-HT1A receptor agonist BAY R 1531 blocked, whereas, WAY 100135 and gepirone intensified 30-bites analgesia.
"
03/26/1998 - "
Four to five days after guide-cannula implantation, each mouse received microinjection of gepirone (30 nmol/0.2 microl), BAY R 1531 (10 nmol/0.2 microl), WAY 100135 (10 nmol/0.2 microl), saline (0.9% NaCl) or vehicle (saline + 4% Tween 80) 5 min before either an aggressive (30 bites) or a non-aggressive interaction.
"
Related Drugs and Biologics
1.
gepirone
2.
8-Hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT)
3.
ipsapirone
4.
5-HT1A Serotonin Receptor
5.
Polysorbates (PSML)
6.
Buspirone (Buspar)
7.
Saline Solution
8.
WAY 100135
Related Therapies and Procedures
1.
Analgesia
2.
Cannula