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L 670596
thromboxane and prostaglondin endoperoxide receptor antagoist; structure given in first source
Also Known As:
L-670,596; 1H-Carbazole-1-acetic acid, 6,8-difluoro-2,3,4,9-tetrahydro-9-((4-(methylsulfonyl)phenyl)methyl)-, (-)-
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
Carbazoles: 32
L 670596: 2
3-Ring Heterocyclic Compounds
Carbazoles: 32
L 670596: 2
Related Diseases
1.
Respiratory Hypersensitivity
09/01/1990 - "
In this study, two thromboxane receptor antagonists, L-655,240 and L-670,596, were used in doses that inhibit the response to an inhaled thromboxane mimetic, U-46619, to determine further the role of thromboxane in ozone-induced airway hyperresponsiveness.
"
2.
Coronary Thrombosis
04/01/1994 - "
In the dog model of electrically induced coronary thrombosis, occlusion time in control animals (n = 14) averaged 72 +/- 29 min. L 670596 alone dose-dependently antagonized platelet PGH2/TXA2 receptors and prolonged occlusion time.
"
Related Drugs and Biologics
1.
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
2.
Thromboxane Receptors (Thromboxane Receptor)
3.
Thromboxanes
4.
Ozone
5.
Prostaglandin H2 (PGH(2))