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fantofarone
structure given in first source
Also Known As:
2-isopropyl-1-((4-(3-(N-methyl-N-(3,4-dimethoxy-beta-phenethyl)amino)propoxy)benzenesulfonyl))indolizine; SR 33557; SR-33557; Benzeneethanamine, 3,4-dimethoxy-N-methyl-N-(3-(4-((2-(1-methylethyl)-1-indolizinyl)sulfonyl)phenoxy)propyl)-
Networked:
5
relevant articles (
2
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indolizines: 3
fantofarone: 5
Organic Chemicals: 133
Amines: 4871
Ethylamines: 5
Phenethylamines: 28
fantofarone: 5
Related Diseases
1.
Stable Angina
01/01/1997 - "
In doses of 100 mg to 150 mg twice daily, monotherapy fantofarone was effective and safe in the treatment of patients with chronic, stable angina pectoris.
"
01/01/1997 - "
Safety and efficacy of monotherapy with fantofarone, a novel calcium channel antagonist, in patients with chronic stable angina pectoris.
"
2.
Ischemia
01/14/1994 - "
In contrast, a 20-min pretreatment period with 1 microM fantofarone significantly improved the recovery of mechanical performance, metabolic activity and pH after the same 18 min of ischemia.
"
3.
Malaria
02/15/1998 - "
This study describes the synergistic interaction of two calcium channel blockers, verapamil (VR) and SR33557 or fantofarone (SR), in reversing chloroquine resistance in Plasmodium falciparum, the causative agent of human malaria.
"
4.
Coronary Artery Disease (Coronary Atherosclerosis)
01/01/1994 - "
Hemodynamic effects of a new calcium antagonist, SR 33557, in patients with coronary artery disease and normal left ventricular function.
"
5.
Contracture
11/01/1990 - "
In spike-generating vascular smooth muscle (rat portal vein), contractures evoked by noradrenaline (4 microM) or KCl (100 mM) were reduced by all four antagonists, the pharmacological potency being nifedipine greater than SR 33557 greater than verapamil greater than diltiazem.
"
Related Drugs and Biologics
1.
Calcium Channel Blockers (Blockers, Calcium Channel)
2.
Verapamil (Calan)
3.
Chloroquine (Aralen)
4.
Norepinephrine (Noradrenaline)
5.
Nifedipine (Adalat)
6.
Diltiazem (Cardizem)
7.
Calcium