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E 5110
structure given in first source
Also Known As:
E-5110; N-methoxy-3-(3,5-di-tert-butyl-4-hydroxybenzylidene)pyrrolidin-2-one; 2-Pyrrolidinone, 3-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-1-methoxy-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyrrolidines: 115
Pyrrolidinones: 162
E 5110: 3
Related Diseases
1.
Edema (Dropsy)
08/01/1987 - "
The acute antiinflammatory activity of E-5110 on carrageenin paw edema was similar to IND, and half of PIR.
"
08/01/1987 - "
The acute antiinflammatory activity of E-5110 on the carrageenin paw edema was similar to that of indomethacin, and half that of piroxicam.
"
2.
Arthus Reaction
08/01/1987 - "
E-5110 inhibited the pleural exudate volume and leucocyte infiltration in a reversed passive Arthus reaction more potent than IND.
"
08/01/1987 - "
E-5110 decreased the pleural exudate volume and inhibited leucocyte infiltration in a reversed passive Arthus reaction more potently than indomethacin, suggesting that mediators other than prostaglandin E2 may play an important role in this inflammatory process.
"
3.
Rheumatoid Arthritis
06/01/1989 - "
It is expected that E-5110 will be superior to classical non-steroidal antiinflammatory drugs in medical treatment of rheumatoid arthritis.
"
08/01/1987 - "
The chronic inflammatory responses in established adjuvant- and type II collagen-induced arthritis, which are widely used models of rheumatoid arthritis, were suppressed as effectively by E-5110 as by indomethacin and piroxicam.
"
4.
Arthritis (Polyarthritis)
08/01/1987 - "
The chronic inflammatory responses in the established adjuvant- and type II collagen-induced arthritis were suppressed by E-5110 similar to IND and PIR.
"
08/01/1987 - "
The chronic inflammatory responses in established adjuvant- and type II collagen-induced arthritis, which are widely used models of rheumatoid arthritis, were suppressed as effectively by E-5110 as by indomethacin and piroxicam.
"
5.
Pain (Aches)
08/01/1987 - "
The analgesic potency of E-5110 against inflammatory pain was similar to that of indomethacin or piroxicam, but the antipyretic activity of E-5110 was more potent than that of the reference drugs.
"
Related Drugs and Biologics
1.
Collagen Type II (Type II Collagen)
2.
Carrageenan
3.
Antipyretics
4.
Dinoprostone (PGE2)
5.
Piroxicam (Feldene)
6.
Indomethacin (Indometacin)
7.
Analgesics (Analgesic Drugs)