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CM 57493
structure given in first source
Also Known As:
4-(3-trifluoromethylphenyl)-1-(2-cyanoethyl)-1,2,3,6-tetrahydropyridine HCl; CM-57493; 1(2H)-Pyridinepropanenitrile, 3,6-dihydro-4-(3-(trifluoromethyl)phenyl)-
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridines: 88
CM 57493: 2
Related Diseases
1.
Ischemia
10/15/1991 - "
Furthermore, 1 and 5 mg/kg CM 57493 significantly reduced the neuronal damage within the CA1 sector of the rat hippocampus after 10 min of forebrain ischemia followed by 7 days of recovery.
"
12/10/1993 - "
Administration of the 5-HT1A agonist CM 57493 reduced the neuronal damage within the ventral hippocampus and the entorhinal cortex as assessed histologically 7 days after ischemia.
"
2.
Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
10/15/1991 - "
After middle cerebral artery-occlusion (MCA-0) in mice, the infarct size was reduced dose dependently by both urapidil and CM 57493.
"
3.
Infarction (Infarctions)
10/15/1991 - "
In MCA-occluded rats, CM 57493 (1 and 5 mg/kg) reduced the cortical infarct volume by 30% and application of 10 mg/kg CM 57493 led to a 40% reduction in the cortical infarct volume.
"
10/15/1991 - "
After middle cerebral artery-occlusion (MCA-0) in mice, the infarct size was reduced dose dependently by both urapidil and CM 57493.
"
4.
Brain Ischemia (Cerebral Ischemia)
10/15/1991 - "
We tested urapidil and a new 5-HT1A agonist, CM 57493 [4-(3-trifluoromethylphenyl)-1-(2-cyanoethyl)-1,2,3,6-tetrahydropyridine ], for their neuroprotective activity in models of focal and global cerebral ischemia in rodents.
"
Related Drugs and Biologics
1.
Serotonin 5-HT1 Receptor Agonists
2.
Pyrrolidines
3.
urapidil