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L 640035
inhibits human platelet aggregation induced by arachidonic acid, collagen & prostaglandin endoperoxide analog of U44069
Also Known As:
3-hydroxymethyldibenzo(b,f)thiepin 5,5-dioxide; L-640,035; L-640035; Dibenzo(b,f)thiepin-3-methanol, 5,5-dioxide
Networked:
3
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Sulfur Compounds: 278
Thiepins
Dibenzothiepins
L 640035: 3
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
3-Ring Heterocyclic Compounds
Dibenzothiepins
L 640035: 3
Related Diseases
1.
Asthma (Bronchial Asthma)
08/01/1984 - "
It was concluded first that contractile prostanoids may be important mediators of antigen-induced bronchoconstriction and secondly that L-640,035 may be effective in human allergic asthma.
"
2.
Myocardial Ischemia (Ischemic Heart Diseases)
12/01/1984 - "
A new antagonist of the vasoconstrictor eicosanoids, L-640,035, was studied in a standardized model of myocardial ischemia (MI) in anesthetized cats.
"
3.
Bronchial Hyperreactivity
08/01/1984 - "
The effects of an antagonist of contractile prostanoids, L-640,035 (3-hydroxymethyl-dibenzo[b,f]thiepin-5-dioxide) upon antigen-induced bronchoconstriction have been studied in inbred rats with non-specific bronchial hyperreactivity and in conscious squirrel monkeys.
"
4.
Pulmonary Hypertension
04/01/1987 - "
Cotreatment with L-640,035 did not attenuate the increase in lung weight, lavage fluid lactate dehydrogenase activity or protein concentration, or the pulmonary hypertension caused by MCTP.
"
5.
Dyspnea (Shortness of Breath)
08/01/1984 - "
L-640,035 was a potent inhibitor of antigen-induced dyspnea (ED50 3.1 mg/kg p.o.) in inbred rats pretreated with methysergide (3 micrograms/kg i.v.) but produced no significant inhibition in untreated rats.
"
Related Drugs and Biologics
1.
Prostaglandins
2.
Antigens
3.
Eicosanoids
4.
Vasoconstrictor Agents
5.
Proteins (Proteins, Gene)
6.
Methysergide (Sansert)
7.
L-Lactate Dehydrogenase (Lactate Dehydrogenase)
8.
1- methyl- 4- cyclohexyl- 1,2,3,6- tetrahydropyridine