tribulin

endogenous MONOAMINE OXIDASE inhibitory activity extractable into ethyl acetate found in brain and many mammalian tissues and fluids; ISATIN is a major component; produced in excess following alcohol withdrawal;

Networked: 17 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sinitskiy, A I: 1 article (01/2015)
2.	Vinogradov, D B: 1 article (01/2015)
3.	Axenova, L N: 1 article (01/2000)
4.	Medvedev, A E: 1 article (01/2000)
5.	Panova, N G: 1 article (01/2000)

Related Diseases

1.	Panic Disorder (Panic Attack) 02/01/1988 - "Urinary tribulin output in patients with panic attacks." 01/01/1989 - "Similarly studies of the endogenous MAO inhibitor, tribulin, suggest that the output in panic disorder patients is similar to that of controls. " 01/01/1985 - "Tribulin output has been found to be increased in a variety of states associated with stress and anxiety, including lactate-induced panic attacks, alcohol or benzodiazepine withdrawal and generalized anxiety disorder." 01/01/1988 - "Urinary output of homovanillic acid and 4-hydroxy-3-methoxymandelic acid was decreased both in patients with panic attacks and in normal controls during lactate infusion, whereas that of tribulin (an endogenous monoamine oxidase inhibitor and benzodiazepine receptor binding inhibitor) was increased. "
2.	Inflammation (Inflammations) 01/01/1991 - "The increase in rat brain tribulin activity closely paralleled the time course intensity of the inflammation. " 01/01/1991 - "The study indicates that, like externally induced stress, internal stress caused by the inflammation induced hyperalgesia can also induce augmented brain tribulin activity. " 01/01/1991 - "Rat brain endogenous MAO inhibitor (tribulin) activity during carrageenan-induced acute paw inflammation." 01/01/1991 - "The endogenous monoamine oxidase (MAO) inhibitor (tribulin) activity of rat brain was investigated during the course of carrageenan induced acute paw inflammation. "
3.	Hyperalgesia 01/01/1991 - "The study indicates that, like externally induced stress, internal stress caused by the inflammation induced hyperalgesia can also induce augmented brain tribulin activity. "
4.	Anxiety Disorders (Anxiety Disorder) 01/01/1988 - "Increased urinary tribulin output in generalised anxiety disorder." 10/01/1989 - "These findings suggest that the biochemical nature of the anxiety associated with migraine may differ from that in other conditions such as generalized anxiety disorder where high platelet MAO activity and high tribulin output have been reported." 01/01/1988 - "Urinary output of an endogenous monoamine oxidase inhibitor and benzodiazepine receptor binding inhibitor (tribulin) was raised in a group of patients with generalised anxiety disorder compared with controls. " 01/01/1985 - "Tribulin output has been found to be increased in a variety of states associated with stress and anxiety, including lactate-induced panic attacks, alcohol or benzodiazepine withdrawal and generalized anxiety disorder."
5.	Alcoholism (Alcohol Abuse) 01/01/2000 - "Taking into consideration some ethanol-induced decrease of brain tribulin content we suggest that the reduced level of endogenous inhibitors (tribulin components?) may have some importance in the development of alcoholism." 01/01/1999 - "It was shown that deficiency of tribulin components that selectively inhibited MAO A long with a larger number of molecules of this enzyme might be of great importance for the development of alcoholism. "

Related Drugs and Biologics

1.	Monoamine Oxidase Inhibitors (Monoamine Oxidase Inhibitor)
2.	Monoamine Oxidase (MAO)
3.	GABA-A Receptors (GABA(A) Receptor)
4.	Lactic Acid (Lactate)
5.	Vanilmandelic Acid (Vanillylmandelic Acid)
6.	Serotonin (5 Hydroxytryptamine)
7.	Norepinephrine (Noradrenaline)
8.	Ligands
9.	Isatin
10.	Hydrocortisone (Cortisol)