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nordimaprit
effective agonist in the inhibition of lymphocyte activation
Also Known As:
2-(S-dimethylaminoethyl)isothiourea; S-(2-(diethylamino)-ethyl)-isothiouronium HCl; SK&F 91487; SK&F-91487; SKF-91487; nordimaprit dihydrochloride; persulfate bleach accelerator
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amides: 2428
Urea: 15015
Thiourea: 362
Dimaprit: 54
nordimaprit: 5
Sulfur Compounds: 278
Thiourea: 362
Dimaprit: 54
nordimaprit: 5
Related Diseases
1.
Melanoma (Melanoma, Malignant)
07/06/1993 - "
Inhibition of melanogenesis in human melanoma cells by novel analogues of the partial histamine (H2) agonist nordimaprit.
"
07/06/1993 - "
A series of analogues of the weak histamine (H2) agonist S-[2-(N,N-dimethylamine)ethyl] isothiourea (nordimaprit) was produced to investigate the possibility that bulky substituents on the tertiary amine of nordimaprit would enhance potency for depigmentation and killing of melanoma cells.
"
05/28/1992 - "
Human melanoma cells were treated in culture with the histamine (H2) agonist S-(3-(N-N-dimethylamino)propyl)isothiourea (dimaprit), a partial agonist, S-(2-(N,N-dimethylamino)ethyl)-isothiourea (nordimaprit), and two analogues of nordimaprit, S-(2-(N,N-diethylamino)ethyl)isothiourea (DENOR) and S-(2-(N,N-diisopropylamino)ethyl)isothiourea (DINOR), to investigate the effects on toxicity and tyrosinase activity.
"
11/01/1991 - "
In cultured human melanoma cells, histamine H1 (mepyramine) and H2 receptor antagonists (cimetidine, ranitidine, impromidine) increased tyrosinase activity, whereas H2 agonists (dimaprit, nordimaprit) decreased activity.
"
2.
Anterior Uveitis
10/01/1986 - "
Eosinophil chemotaxis and anterior uveitis from topical dimaprit and nordimaprit.
"
3.
Anaphylaxis (Anaphylactic Shock)
03/01/1987 - "
Nordimaprit and the selective H1-receptor agonist 2-pyridyl-ethyl-amine (2-PEA) did not modify the patterns of cardiac anaphylaxis.
"
03/01/1987 - "
The H2-receptor agonists decrease the amount of histamine released during cardiac anaphylaxis which is increased by cimetidine, while nordimaprit and PEA were ineffective, indicating an inhibitory function afforded by H2-receptors in cardiac anaphylaxis.
"
Related Drugs and Biologics
1.
Histamine Agonists
2.
Dimaprit
3.
Monophenol Monooxygenase (Tyrosinase)
4.
Histamine (Histamine Dihydrochloride)
5.
Cimetidine (Biomet)
6.
Impromidine (SK&F-92676)
7.
Ranitidine (Zantac)
8.
Pyrilamine (Mepyramine)
9.
Amines
10.
S- (2- (N,N- diisopropylamino)ethyl)isothiourea