guanylyltransferase

guanylation of heterologous RNA containing 2 or 3 phosphate or G(5')pppN at their 5' terminal; transfer of a GMP moiety from GTP to the 5' end of an RNA molecule containing at least two terminal phosphate

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Cui, Yanxiang: 1 article (01/2021)
2.	Johnson, Patricia J: 1 article (01/2021)
3.	Muratore, Katherine: 1 article (01/2021)
4.	Stevens, Alexander: 1 article (01/2021)
5.	Zhou, Z Hong: 1 article (01/2021)
6.	Ansari, Mohammad Yunus: 1 article (02/2019)
7.	Bellur, Asutosh: 1 article (02/2019)
8.	Rajagopalan, Deepa: 1 article (02/2019)
9.	Shaila, Melkote Subbarao: 1 article (02/2019)
10.	Shanmugam, Purnima: 1 article (02/2019)

Related Diseases

1.	Vaccinia 05/01/1983 - "The RNA product was capped using the vaccinia guanylyltransferase. " 07/15/1990 - "Guanylyltransferase sedimented as a single component of 6.5 S during further purification in a glycerol gradient; this S value is identical with that of the heterodimeric capping enzyme from vaccinia virions. " 12/10/1980 - "The GTP-PPi exchange reaction of vaccinia guanylyltransferase affords a simple, sensitive assay for capping enzyme function. " 03/20/1989 - "We suggest that a lack of coupling between the vaccinia viral RNA guanylyltransferase and bacteriophage T7 RNA polymerase delays capping of T7 transcripts and that, under these conditions, the 5'-terminal double-stranded stem is required to stabilize the nascent RNA against degradation. " 07/05/1985 - "Intact primer RNA for discontinuous DNA replication of Escherichia coli has been detected by specific labeling in vitro of its 5'-terminal tri- (or di-) phosphate group with vaccinia guanylyltransferase and [alpha-32P]GTP. "
2.	Dengue (Dengue Fever) 01/01/2023 - "Effects of Glutathionylation on Guanylyltransferase Activity of NS5 N-terminal Capping Domain from Dengue, Japanese Encephalitis, and Zika Viruses." 01/01/2018 - "Glutathionylation of dengue and Zika NS5 proteins affects guanylyltransferase and RNA dependent RNA polymerase activities." 01/01/2018 - "Then we generated two flavivirus recombinant full length proteins, dengue NS5 and Zika NS5, to characterize two of the NS5 enzyme activities, namely, guanylyltransferase and RNA-dependent RNA polymerase activities. "
3.	Cysts 04/22/1994 - "GTP:GTP guanylyltransferase has been purified from the yolk platelets of Artemia cysts. " 01/01/1999 - "The chemical nature of the enzyme-nucleotide phosphoramidate reaction intermediate employed by the unique GTP:GTP guanylyltransferase from yolk platelets of Artemia franciscana cysts to synthesize diguanosine tetraphosphate (Gp4G) has been investigated. "
4.	Vesicular Stomatitis 02/01/2019 - "We have found earlier that the L protein of RPV has RNA triphosphatase (RTPase), guanylyltransferase (GTase) and methyltransferase activities, and unlike vesicular stomatitis virus (VSV), follows the conventional pathway of mRNA capping. "
5.	Trichomonas Infections 01/01/2021 - "Structural comparison of TVV2 to the Saccharomyces cerevisiae L-A virus reveals a conserved helix-rich fold within the CSP and putative guanylyltransferase domain along the capsid exterior, suggesting conserved mRNA maintenance strategies among Totiviridae This first atomic structure of a TVV provides a framework to guide future biochemical investigations into the interplay between Trichomonas vaginalis and its viruses.IMPORTANCETrichomonas vaginalis viruses (TVVs) are double-stranded RNA (dsRNA) viruses that cohabitate in Trichomonas vaginalis, the causative pathogen of trichomoniasis, the most common nonviral sexually transmitted disease worldwide. "

Related Drugs and Biologics

1.	Guanosine Triphosphate (GTP)
2.	RNA (Ribonucleic Acid)
3.	Enzymes
4.	Messenger RNA (mRNA)
5.	Proteins (Proteins, Gene)
6.	Phosphates (Orthophosphate)
7.	Methyltransferases
8.	Viral RNA
9.	Transfer RNA (tRNA)
10.	Double-Stranded RNA (RNA, Double Stranded)