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hippuryl-histidyl-leucine
synthetic substrate for angiotensin converting enzyme; used in affinity chromatography
Also Known As:
Bz-Gly-His-Leu; Hip-His-Leu; N-(N-(N-benzoylglycyl)-L-histidinyl)-L-leucine; benzoyl-glycyl-histidyl-leucine; hippuryl-His-Leu; hippuryl-L-histidyl-L-leucine
Networked:
9
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
hippuryl-histidyl-leucine: 9
Related Diseases
1.
Sarcoidosis (Schaumann Disease)
01/01/1979 - "
Using a spectrophotometric assay with L-hippuryl-L-histidyl-L-leucine as substrate, s-angiotensin-converting enzyme (SACE) was determined in 85 sarcoidosis patients, 116 healthy controls and 150 patients with various non-sarcoid diseases.
"
10/01/1977 - "
The activity of serum angiotensin converting enzyme (ACE), assayed fluorometrically with the substrate hippuryl-L-histidyl-L-leucine was significantly higher in 116 patients with sarcoidosis than in 415 patients with other diseases--pulmonary and nonpulmonary--and in 58 normal subjects.
"
2.
Lung Diseases (Lung Disease)
09/01/1975 - "
The assay was performed in approximately 200 control subjects and 200 patients with chronic lung disease using hippuryl-L-histidyl-L-leucine as substrate.
"
10/01/1977 - "
The activity of serum angiotensin converting enzyme (ACE), assayed fluorometrically with the substrate hippuryl-L-histidyl-L-leucine was significantly higher in 116 patients with sarcoidosis than in 415 patients with other diseases--pulmonary and nonpulmonary--and in 58 normal subjects.
"
3.
Asthma (Bronchial Asthma)
01/01/1978 - "
Using hippuryl-L-histidyl-L-leucine as a substrate analogue, serum angiotensin converting enzyme (ACE) was spectrophotometrically estimated in patients with bronchial asthma.
"
02/01/1977 - "
Using hippuryl-L-histidyl-L-leucine as a substrate analog, serum angiotensin converting enzyme (ACE) was spectrophotometrically estimated in patients with bronchial asthma.
"
4.
Pulmonary Sarcoidosis
01/01/1985 - "
Mean values for serum angiotensin-I-converting enzyme (SACE), determined spectrophotometrically in 648 subjects, using the synthetic substrate hippuryl-L-histidyl-L-leucine, and expressed in units per milliliter, were: controls, 11.11 +/- 3.97 (n = 89); lung cancer, 6.50 +/- 3.26 (n = 87); tuberculosis of the lung, 8.93 +/- 4.60 (n = 68); pulmonary sarcoidosis, 21.18 +/- 14.93 (n = 48); pneumonia, 9.81 +/- 6.83 (n = 52); fibrosis, 11.18 +/- 8.26 (n = 34); diabetes mellitus, 10.90 +/- 7.51 (n = 29); ischemic heart disease, 8.98 +/- 6.19 (n = 42); pulmonary embolism, 13.20 +/- 3.91 (n = 5); and lymphomas, 11.66 +/- 5.44 (n = 36).
"
5.
Myocardial Ischemia (Ischemic Heart Diseases)
01/01/1985 - "
Mean values for serum angiotensin-I-converting enzyme (SACE), determined spectrophotometrically in 648 subjects, using the synthetic substrate hippuryl-L-histidyl-L-leucine, and expressed in units per milliliter, were: controls, 11.11 +/- 3.97 (n = 89); lung cancer, 6.50 +/- 3.26 (n = 87); tuberculosis of the lung, 8.93 +/- 4.60 (n = 68); pulmonary sarcoidosis, 21.18 +/- 14.93 (n = 48); pneumonia, 9.81 +/- 6.83 (n = 52); fibrosis, 11.18 +/- 8.26 (n = 34); diabetes mellitus, 10.90 +/- 7.51 (n = 29); ischemic heart disease, 8.98 +/- 6.19 (n = 42); pulmonary embolism, 13.20 +/- 3.91 (n = 5); and lymphomas, 11.66 +/- 5.44 (n = 36).
"
Related Drugs and Biologics
1.
Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
2.
Enzymes
3.
Carboxypeptidases
4.
Captopril (Capoten)
5.
phenylalanylarginine
6.
dipeptidyl carboxypeptidase (peptidyl-dipeptidase Dcp)