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murexine
muscle relaxant; structure
Also Known As:
beta- (4-imidazolyl)acryloylcholine; choline, chloride, imidazole-4-acrylate
Networked:
4
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Quaternary Ammonium Compounds: 136
Trimethyl Ammonium Compounds: 1
Choline: 6256
murexine: 4
Amino Alcohols: 20
Ethanolamines: 16
Choline: 6256
murexine: 4
Alcohols: 595
Amino Alcohols: 20
Ethanolamines: 16
Choline: 6256
murexine: 4
Onium Compounds
Quaternary Ammonium Compounds: 136
Choline: 6256
murexine: 4
Related Diseases
1.
Contracture
09/01/1957 - "
Murexine (urocanoylcholine, [2-beta-imidazol-4(5)-ylacryloyloxyethyl]trimethylammonium chloride hydrochloride) produced a contracture like acetylcholine in the frog rectus and a neuromuscular block in the rat diaphragm which was not relieved by neostigmine but was antagonized by hexamethonium.
"
2.
Ganglion Cysts (Ganglion)
09/01/1958 - "
DMAC has been shown to be a ganglion stimulating and neuromuscular blocking agent generally similar, in potency and properties, to murexine.
"
03/01/1958 - "
Murexine (urocanoylcholine, [2-beta-imidazol-4(5)-ylacryloyloxyethyl] trimethylammonium bromide) has been shown to possess ganglion stimulating and neuromuscular blocking actions in cat, dog and rat.
"
3.
Spasm (Spasms)
01/01/1970 - "
Four other imidazoles tested, L-histidine, murexine, dihydromurexine and imidazolecarboxylcholine, were ineffective; so was the pyrazole ring isomer of histamine, betazole.4. The inhibitory action of histamine persisted after adrenoceptor blockade by phentolamine and pronethalol and after prior reserpinization of the guineapigs.5. The inhibitory action of histamine was also obtained after ganglionic paralysis by hexamethonium or dimethylphenylpiperazinium but was antagonized specifically by nicotine.6. On atropinized preparations of the longitudinal muscle from the guinea-pig descending colon histamine exerted, at most, an insignificant inhibitory effect on the tetanic spasms.
"
4.
Paralysis (Palsy)
01/01/1970 - "
Four other imidazoles tested, L-histidine, murexine, dihydromurexine and imidazolecarboxylcholine, were ineffective; so was the pyrazole ring isomer of histamine, betazole.4. The inhibitory action of histamine persisted after adrenoceptor blockade by phentolamine and pronethalol and after prior reserpinization of the guineapigs.5. The inhibitory action of histamine was also obtained after ganglionic paralysis by hexamethonium or dimethylphenylpiperazinium but was antagonized specifically by nicotine.6. On atropinized preparations of the longitudinal muscle from the guinea-pig descending colon histamine exerted, at most, an insignificant inhibitory effect on the tetanic spasms.
"
Related Drugs and Biologics
1.
Hexamethonium (Hexamethonium Bromide)
2.
Neostigmine (Neostigmine Bromide)
3.
Chlorides
4.
Acetylcholine (Acetylcholine Chloride)
5.
Adrenergic Receptors (Adrenergic Receptor)
6.
Phentolamine (Z-Max)
7.
Nicotine
8.
Neuromuscular Blocking Agents
9.
Imidazoles
10.
Histidine (L-Histidine)