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galactosylhydroxylysine
found in collagen & basement membranes; presence in urine can be used to determine collagen metabolism
Also Known As:
beta-1-galactosyl-O-hydroxylysine; hydroxylysine-galactose; L-Lysine, 5-(beta-D-galactopyranosyloxy)-
Networked:
4
relevant articles (
0
outcomes,
2
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Basic Amino Acids: 178
Lysine: 6737
Hydroxylysine: 116
galactosylhydroxylysine: 4
Diamino Amino Acids: 101
Lysine: 6737
Hydroxylysine: 116
galactosylhydroxylysine: 4
Related Diseases
1.
Bone Resorption
11/01/1998 - "
Galactosylhydroxylysine (GHL) is released during bone resorption and has been shown to be elevated in subjects with metabolic bone loss.
"
07/01/1994 - "
Galactosylhydroxylysine appears to be a sensitive index of bone resorption, useful in the clinical assessment of bone involvement and in the management of patients with mild primary hyperparathyroidism.
"
07/01/1994 - "
Galactosylhydroxylysine, an amino acid mainly represented in bone collagen, has been proposed as a more suitable index of bone resorption.
"
09/01/1997 - "
The aim of this study was to compare urinary galactosylhydroxylysine (GHyl) and deoxypyridinoline (d-Pyr) as biochemical markers of bone resorption in post-menopausal women treated and untreated with estrogen and cyclic etidronate.
"
2.
Primary Hyperparathyroidism
07/01/1994 - "
Galactosylhydroxylysine appears to be a sensitive index of bone resorption, useful in the clinical assessment of bone involvement and in the management of patients with mild primary hyperparathyroidism.
"
07/01/1994 - "
Effect of bisphosphonate therapy and parathyroidectomy on the urinary excretion of galactosylhydroxylysine in primary hyperparathyroidism.
"
07/01/1994 - "
In this study we evaluated the sensitivity of galactosylhydroxylysine and hydroxyproline assays in following the changes of their urinary levels in 12 patients with mild primary hyperparathyroidism before and after treatment with bisphosphonate and surgery.
"
3.
Neoplasm Metastasis (Metastasis)
03/15/1979 - "
The excretion of glucosylgalactosylhydroxylysine and galactosylhydroxylysine was increased in all patients with carcinoma metastases in bone while the excretion of glucosylgalactosylhydroxylysine in patients with Paget's disease.
"
4.
Carcinoma (Carcinomatosis)
03/15/1979 - "
The excretion of glucosylgalactosylhydroxylysine and galactosylhydroxylysine was increased in all patients with carcinoma metastases in bone while the excretion of glucosylgalactosylhydroxylysine in patients with Paget's disease.
"
5.
Bone Diseases (Bone Disease)
03/15/1979 - "
Both forms of bone disease resulted in an increased excretion of total hydroxyproline and the ratio of glucosylgalactosylhydroxylsine to galactosylhydroxylysine was below normal.
"
Related Drugs and Biologics
1.
Hydroxyproline (4 Hydroxyproline)
2.
Biomarkers (Surrogate Marker)
3.
Etidronic Acid (HEDP)
4.
Estrogens (Estrogen)
5.
Diphosphonates (Bisphosphonates)
6.
deoxypyridinoline
7.
Collagen
8.
Amino Acids
9.
glucosylgalactosylhydroxylysine
Related Therapies and Procedures
1.
Aftercare (After-Treatment)
2.
Parathyroidectomy
3.
Therapeutics