zabedosertib

IRAK4 kinase inhibitor

Also Known As:

BAY-1834845; BAY1834845; N-(6-(1-hydroxy-1-methyl-ethyl)-2-(2-methylsulfonylethyl)indazol-5-yl)-6-(trifluoromethyl)pyridine-2-carboxamide

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

1.	Lung Injury 09/01/2022 - "Unexpectedly, although both compounds had excellent IC50 on IRAK4 kinase activity, only BAY-1834845 but not PF-06650833 or high dose dexamethasone could significantly prevent lung injury according to a blinded pathology scoring. "
2.	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 09/01/2022 - "Oral IRAK4 inhibitor BAY-1834845 prevents acute respiratory distress syndrome."

1.	Phosphotransferases (Kinase)
2.	Dexamethasone (Maxidex)
3.	1- (((2S,3S,4S)- 3- ethyl- 4- fluoro- 5- oxopyrrolidin- 2- yl)methoxy)- 7- methoxyisoquinoline- 6- carboxamide