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GSK-3 kinase inhibitor pym-5

Also Known As:

pym-5

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - GSK-3 kinase inhibitor pym-5: 1
  - Piperazines: 26
    - GSK-3 kinase inhibitor pym-5: 1

Experts

1.	Jia, Qi: 1 article (06/2022)
2.	Lu, Tao: 1 article (06/2022)
3.	Lu, Yin: 1 article (06/2022)
4.	Song, Li: 1 article (06/2022)
5.	Tao, Li: 1 article (06/2022)
6.	Wei, Zhonghong: 1 article (06/2022)
7.	Woodgett, James R: 1 article (06/2022)
8.	Zhou, Yinyin: 1 article (06/2022)

Related Diseases

1.

Melanoma (Melanoma, Malignant)

06/01/2022 - "We found that Pym-5 delayed the growth and promoted melanogenesis of melanoma cells. "
06/01/2022 - "Novel GSK-3 kinase inhibitor Pym-5 induces GSK-3β rather than GSK-3α-dependent melanogenesis in murine melanoma cells."
06/01/2022 - "Using Pym-5 as a chemical tool to probe the GSK-3 biology, we aimed to investigate the potential of GSK-3 inhibition as a strategy of melanoma treatment and underlying mechanisms. "
06/01/2022 - "These data provide insight into the potential therapeutic benefits obtained from activation of Wnt/β-Catenin signaling pathway and how Pym-5 can regulate melanin production and the rationale for future clinical application of GSK-3 inhibitor in melanoma patients."

Related Drugs and Biologics

1.	Catenins
2.	Glycogen Synthase Kinase 3
3.	Melanins (Melanin)