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DA-9805

a mixed herbal ethanol extract containing Moutan cortex Radicis, Bupleurum falcatum L, and Angelica dahurica

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Biological Products
  - Plant Preparations: 622
    - Plant Extracts: 3916
      - DA-9805: 4
Pharmaceutical Preparations
- Plant Extracts: 3916
  - DA-9805: 4

Experts

1.	Hong, Seon-Pyo: 3 articles (01/2022 - 10/2018)
2.	Jeong, Jin Seok: 3 articles (01/2022 - 10/2018)
3.	Oh, Myung Sook: 3 articles (01/2022 - 10/2018)
4.	Pak, Youngmi Kim: 3 articles (01/2022 - 10/2018)
5.	Choi, Jin Gyu: 2 articles (01/2022 - 09/2019)
6.	Huh, Eugene: 2 articles (01/2022 - 09/2019)
7.	Kang, Sora: 2 articles (01/2022 - 10/2018)
8.	Kang, Young Cheol: 2 articles (01/2022 - 10/2018)
9.	Kwon, Youngji: 2 articles (01/2022 - 09/2019)
10.	Piao, Ying: 2 articles (01/2022 - 10/2018)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 09/01/2019 - "Protective effects of DA-9805 on dopaminergic neurons against 6-hydroxydopamine-induced neurotoxicity in the models of Parkinson's disease." 10/29/2018 - "Triple herbal extract DA-9805 exerts a neuroprotective effect via amelioration of mitochondrial damage in experimental models of Parkinson's disease." 01/01/2022 - "DA-9805, a Herbal Mixture, Restores Motor Manifestations in 6-Hydroxydopamine-induced Parkinson's Disease Mouse Model by Regulating Striatal Dopamine and Acetylcholine Levels."
2.	Neuroinflammatory Diseases 01/01/2022 - "In the present study, we investigated whether DA-9805 could suppress ER stress and neuroinflammation in vitro and/or in vivo. " 01/01/2022 - "Taken together, these results indicate that DA-9805 can effectively prevent ER stress and neuroinflammation, suggesting that DA-9805 is a multitargeting and disease-modifying therapeutic candidate for PD."
3.	Hypokinesia (Bradykinesia) 10/29/2018 - "In the MPTP-induced subacute PD model mice, oral administration of DA-9805 recovered dopamine content as well as bradykinesia, as determined by the rotarod test. "
4.	Neuroblastoma 01/01/2022 - "Pre-treatment with DA-9805 (1 μg/ml) attenuated upregulation of glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and cleaved caspase-3 in SH-SY5Y neuroblastoma cells treated with thapsigargin (1 µg/ml) or tunicamycin (2 µg/ml). "
5.	Inflammation (Inflammations) 01/01/2022 - "DA-9805 protects dopaminergic neurons from endoplasmic reticulum stress and inflammation."

Related Drugs and Biologics

1.	Dopamine (Intropin)
2.	Caspase 3 (Caspase-3)
3.	Transcription Factor CHOP
4.	Thapsigargin
5.	Neuroprotective Agents
6.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
7.	Tunicamycin
8.	Proteins (Proteins, Gene)
9.	Glucose (Dextrose)
10.	Acetylcholine (Acetylcholine Chloride)

Related Therapies and Procedures

1.	Oral Administration