Crazy paving pattern

Nonspecific radiological finding in the lung characterized by diffuse ground glass attenuation with reticulation from thickening of the intra- and inter-lobular septa, resembling irregularly shaped paving stones. The pattern is seen in a variety of lung diseases, e.g. INTERSTITIAL LUNG DISEASES; PULMONARY ALVEOLAR PROTEINOSIS and COVID-19.

Also Known As:

Networked: 31 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	COVID-19
2.	Bronchiectasis
3.	Lipid Pneumonia
4.	Pulmonary Alveolar Proteinosis
5.	Pneumonia (Pneumonitis)

Experts

1.	Marchiori, Edson: 3 articles (05/2010 - 10/2008)
2.	Inoue, Yoshikazu: 2 articles (01/2015 - 11/2014)
3.	Zanetti, Gláucia: 2 articles (05/2010 - 10/2008)
4.	Gasparetto, Taisa Davaus: 2 articles (01/2009 - 10/2008)
5.	Aoki, Kotaro: 1 article (07/2022)
6.	Ishikawa, Kazuhiro: 1 article (07/2022)
7.	Kawai, Fujimi: 1 article (07/2022)
8.	Matsuo, Takahiro: 1 article (07/2022)
9.	Mori, Nobuyoshi: 1 article (07/2022)
10.	Murakami, Hinako: 1 article (07/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Crazy paving pattern:

1.	SugarsIBA 01/01/2021 - "Residual ground glass opacities, consolidations, reticular and linear opacities, residual crazy paving pattern, melted sugar sign, and parenchymal fibrotic bands are several features found in the late or remission stages of COVID-19. "
2.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 11/04/2014 - "The patient was a 75-year-old Japanese man diagnosed with aPAP based on the crazy-paving appearance on high-resolution computed tomography (HRCT), "milky" appearance of broncho-alveolar lavage fluid (BALF), and elevated serum levels of the anti-GM-CSF antibody. " 01/01/2015 - "Two years after anti-fungal therapy, he was diagnosed with autoimmune pulmonary alveolar proteinosis (APAP) according to a crazy paving pattern in computed tomography scans of the chest, milky bronchoalveolar lavage effluent, and positive anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody in the serum. "
3.	CollagenIBA 04/01/2017 - "Crazy paving pattern is the name given to characteristic polygonal pattern of interlobular thickening on computed tomography (CT scan) of the lung, which results from accumulation of collagen, interstitial fluid, cell, or other pathology and may be seen in multiple clinical conditions including metastatic cancer as described in this case." 01/01/2018 - " presence of a crazy-paving pattern together with a progressive fall in haemoglobin levels suggests diffuse alveolar haemorrhage (DAH).A panel for collagen vascular diseases and vasculitis should be immediately performed in patients suspected of having DAH."
4.	Acetaminophen (Paracetamol)FDA LinkGeneric 11/04/2014 - "The patient was a 75-year-old Japanese man diagnosed with aPAP based on the crazy-paving appearance on high-resolution computed tomography (HRCT), "milky" appearance of broncho-alveolar lavage fluid (BALF), and elevated serum levels of the anti-GM-CSF antibody. " 01/01/2015 - "Two years after anti-fungal therapy, he was diagnosed with autoimmune pulmonary alveolar proteinosis (APAP) according to a crazy paving pattern in computed tomography scans of the chest, milky bronchoalveolar lavage effluent, and positive anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody in the serum. "
5.	4- ((1,4,8,11- tetraazacyclotetradec- 1- yl)methyl)benzoic acidIBA 01/01/2022 - "A repeat CTPA showed increase reticulations and crazy paving pattern with reduction in lung volume. " 12/01/2020 - "Also, we identified an extremely elevated D-dimer (31.2 mcg/mL), and computed tomography pulmonary angiography (CTPA) revealed an unexpected low thrombus burden and a crazy-paving pattern. "
6.	fibrin fragment D (D-dimer)IBA 12/01/2020 - "Also, we identified an extremely elevated D-dimer (31.2 mcg/mL), and computed tomography pulmonary angiography (CTPA) revealed an unexpected low thrombus burden and a crazy-paving pattern. " 03/01/2021 - "The relationship of these VCs with disease symptoms (fever, cough, shortness of breath), comorbid conditions (diabetes, hypertension, asthma), smoking habit, disease-specific laboratory changes (white blood cell-lymphocyte count, neutrophil/lymphocyte ratio, C-reactive protein [CRP], D-dimer, lactate dehydrogenase [LDH], ferritin, procalcitonin), lung parenchymal infiltration pattern (ground-glass opacity, crazy-paving pattern, consolidation) and its distribution (peripheral, central, mixed, upper lobes, lower lobes, right middle lobe) on CT were investigated by comparison of these variables between patients with and without VCs in chest CT. "
7.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 01/01/2014 - "Cutaneous vasculitis, interstitial pneumonia with crazy-paving appearance on high-resolution computed tomography, and repeated positive perinuclear anti-neutrophil cytoplasmic antibodies (pANCA) are rarely found together in patients with inflammatory bowel disease in the existing literature. "
8.	Surface-Active Agents (Surfactants)IBA 11/01/2014 - "Pulmonary alveolar proteinosis (PAP) is a rare diffuse lung disease caused by abnormal intra-alveolar surfactant accumulation; it commonly appears as a "crazy-paving" pattern on high-resolution computed tomography. "
9.	Mineral Oil (Liquid Paraffin)FDA LinkGeneric 05/01/2010 - "The diagnosis of lipoid pneumonia should be considered in chagasic patients with megaesophagus and a history of aspirating mineral oil, presenting with parenchymal consolidations or crazy-paving pattern in HRCT."
10.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 03/01/2021 - "The relationship of these VCs with disease symptoms (fever, cough, shortness of breath), comorbid conditions (diabetes, hypertension, asthma), smoking habit, disease-specific laboratory changes (white blood cell-lymphocyte count, neutrophil/lymphocyte ratio, C-reactive protein [CRP], D-dimer, lactate dehydrogenase [LDH], ferritin, procalcitonin), lung parenchymal infiltration pattern (ground-glass opacity, crazy-paving pattern, consolidation) and its distribution (peripheral, central, mixed, upper lobes, lower lobes, right middle lobe) on CT were investigated by comparison of these variables between patients with and without VCs in chest CT. "

Therapies and Procedures

1.	Traction 06/01/2022 - "CT images of the patients were reviewed for ground-glass opacities, consolidation, crazy-paving appearance, vascular dilatation, traction bronchiectasis, architectural distortion, and subpleural and parenchymal bands. " 01/01/2022 - "The AUC of radiological-based model on the combination of crazy paving pattern, pure GGO in peripheral area, pure GGO, lesion sizes (1-3 cm), emphysema, and pleural traction is 0.957 (95% CI: 0.924-0.989). " 10/01/2017 - "A chest radiograph showed diffuse bilateral ground-glass opacities with subpleural sparing, crazy-paving pattern, and traction bronchiectasis. " 01/01/2022 - "Temperature, WBC count, crazy paving pattern, pure GGO in peripheral area, pure GGO, lesion sizes (1-3 cm), emphysema, and pleural traction were significantly independent associated with COVID-19. " 01/01/2021 - "Based on the CT images, the common patients were less frequent to exhibit consolidation (odds ratio [OR] = 0.31), pleural effusion (OR = 0.19), lymphadenopathy (OR = 0.17), crazy-paving pattern (OR = 0.22), interlobular septal thickening (OR = 0.27), reticulation (OR = 0.20), traction bronchiectasis (OR = 0.40) with over two lobes involved (OR = 0.07) and central distribution (OR = 0.18) while more frequent to bear unilateral pneumonia (OR = 4.65) involving one lobe (OR = 13.84) or two lobes (OR = 6.95) when compared with severe patients. "
2.	Therapeutics 10/01/2018 - "Following 15 months of anti-fungal therapy, imaging showed reduction in the size of the pulmonary cryptococcoma and new multi-lobar ground-glass opacities interspersed with a crazy-paving pattern. " 01/01/2017 - "CT halo sign and crazy paving pattern due to lung metastases hemorrhage after sunitinib therapy." 01/01/2015 - "Two years after anti-fungal therapy, he was diagnosed with autoimmune pulmonary alveolar proteinosis (APAP) according to a crazy paving pattern in computed tomography scans of the chest, milky bronchoalveolar lavage effluent, and positive anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody in the serum. "
3.	Hematopoietic Stem Cell Transplantation 01/01/2009 - "To describe the pulmonary complications following hematopoietic stem cell transplantation (HSCT) that can present with a "crazy-paving" pattern in high-resolution CT scans. "
4.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 10/13/2008 - "Idiopathic pneumonia syndrome after bone marrow transplantation presenting with "crazy-paving" pattern on high-resolution computed tomography: a case report."
5.	Lipectomy (Liposuction) 06/01/2023 - "Fat Pulmonary Embolism With Crazy-Paving Pattern Opacities and Pneumothorax: A Rare Complication of Liposuction."