SP230

imidazo(1,2-b)pyridazine salt targeting the Toxoplasma gondii calcium-dependent protein kinase 1

Also Known As:

2-(benzo(d)(1,3)dioxol-4-yl)-6-(4-methylpiperazin-1-yl)-3-(pyridin-4-yl)imidazo(1,2-b)pyridazine bis hydrochloride salt

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Debierre-Grockiego, Françoise: 2 articles (07/2021 - 01/2018)
2.	Denevault-Sabourin, Caroline: 2 articles (07/2021 - 01/2018)
3.	Dimier-Poisson, Isabelle: 2 articles (07/2021 - 01/2018)
4.	Héraut, Bruno: 2 articles (07/2021 - 01/2018)
5.	Moiré, Nathalie: 2 articles (07/2021 - 01/2018)
6.	Van Langendonck, Nathalie: 2 articles (07/2021 - 01/2018)
7.	Baron, Firmin: 1 article (07/2021)
8.	Débare, Héloïse: 1 article (07/2021)
9.	Lantier, Louis: 1 article (07/2021)
10.	Brunet, Kévin: 1 article (01/2018)

1.	Toxoplasmosis 01/01/2018 - "Rat and mouse liver microsomes were used to predict half-life and intrinsic clearance, and the pharmacokinetic profile of the most rapidly degraded imidazo[1,2b]pyridazine salt (SP230) was determined in serum, brain and lungs of mice after a single administration of 50 mg/kg. Compounds were then tested in vivo in a murine model of acute toxoplasmosis. " 07/10/2021 - "To develop a more specific and less toxic drug, we have designed SP230, an imidazo[1,2-b]pyridazine salt targeting the Toxoplasma gondii calcium-dependent protein kinase 1 (TgCDPK1) and active against acute toxoplasmosis in mice. "
2.	Congenital Toxoplasmosis 07/10/2021 - "Efficiency of SP230 to inhibit foetal transmission of the parasite was evaluated in a mouse model of congenital toxoplasmosis. "

1.	Salts
2.	pyridazine
3.	calcium-dependent protein kinase