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ONL1204

small peptide antagonist of Fas receptors

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - ONL1204: 1

Experts

1.	Gregory-Ksander, Meredith: 1 article (09/2019)
2.	Kocab, Andrew J: 1 article (09/2019)
3.	Krishnan, Anitha: 1 article (09/2019)
4.	Marshak-Rothstein, Ann: 1 article (09/2019)
5.	Zacks, David N: 1 article (09/2019)

Related Diseases

1.

09/30/2019 - "These results serve as proof-of-principal that the small peptide inhibitor of the Fas receptor, ONL1204, can provide robust neuroprotection in an inducible mouse model of glaucoma, even when administered after IOP elevation. "
09/30/2019 - "Here, we investigated whether targeting the Fas receptor with a small peptide antagonist, ONL1204, has anti-inflammatory and neuroprotective effects in a microbead-induced mouse model of glaucoma. "
09/30/2019 - "Confocal analysis of Iba1-stained retinal flatmounts and qPCR demonstrated that ONL1204 also abrogated microglia activation and inhibited the induction of multiple genes implicated in glaucoma, including cytokines and chemokines (GFAP, Caspase-8, TNFα, IL-1β, IL-6, IL-18, MIP-1α, MIP-1β, MIP-2, MCPI, and IP10), components of the complement cascade (C3, C1Q), Toll-like receptor pathway (TLR4), and inflammasome pathway (NLRP3). "

Related Drugs and Biologics

1.	Inflammasomes
2.	Caspase 8 (Caspase-8)
3.	Toll-Like Receptors (Toll-Like Receptor)
4.	fas Receptor (CD95 Antigen)
5.	Chemokines
6.	Neuroprotective Agents
7.	Cytokines
8.	Retinaldehyde (Retinal)
9.	Peptides (Polypeptides)
10.	Complement System Proteins (Complement)

Related Therapies and Procedures

1.	Microspheres (Microsphere)