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JNJ-63576253

androgen receptor antagonist

Also Known As:

5-(8-Oxo-5-(6-(piperidin-4-yloxy)pyridin-3-yl)-6-thioxo-5,7-diazaspiro(3.4)octan-7-yl)-3-(trifluoromethyl)-picolinonitrile

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - JNJ-63576253: 1
- Nitriles: 227
  - JNJ-63576253: 1
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Picolines: 14
      - JNJ-63576253: 1
    - JNJ-63576253: 1
  - Piperidines: 17
    - JNJ-63576253: 1
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - JNJ-63576253: 1

Experts

1.	Bignan, Gilles: 1 article (01/2021)
2.	Bischoff, James R: 1 article (01/2021)
3.	Branch, Jonathan R: 1 article (01/2021)
4.	Bush, Tammy L: 1 article (01/2021)
5.	Chong, Yolanda T: 1 article (01/2021)
6.	Connolly, Peter J: 1 article (01/2021)
7.	Gottardis, Marco M: 1 article (01/2021)
8.	Habineza, Georges: 1 article (01/2021)
9.	Hickson, Ian: 1 article (01/2021)
10.	Jaensch, Steffen: 1 article (01/2021)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2021 - "Discovery of JNJ-63576253, a Next-Generation Androgen Receptor Antagonist Active Against Wild-Type and Clinically Relevant Ligand Binding Domain Mutations in Metastatic Castration-Resistant Prostate Cancer."
2.	Adenocarcinoma 01/01/2021 - "To address this unmet need, we report the discovery of JNJ-63576253, a next-generation AR pathway inhibitor that potently abrogates AR signaling in models of human prostate adenocarcinoma. "

Related Drugs and Biologics

1.	Androgen Receptor Antagonists
2.	Ligands

Related Therapies and Procedures

1.	Castration