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dopegal

toxic neurotransmitter metabolite

Also Known As:

3,4-dihydroxy-phenylglycolaldehyde

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Aldehydes: 2153
  - Acetaldehyde: 1345
    - dopegal: 4

Experts

1.	Anderson, Ethan J: 1 article (10/2021)
2.	Monroe, T Blake: 1 article (10/2021)
3.	Alessandri-Haber, Nicole: 1 article (09/2008)
4.	Bogen, Oliver: 1 article (09/2008)
5.	Chen, Xiaojie: 1 article (09/2008)
6.	Dina, Olayinka A: 1 article (09/2008)
7.	Green, Paul G: 1 article (09/2008)
8.	Khasar, Sachia G: 1 article (09/2008)
9.	Levine, Jon D: 1 article (09/2008)
10.	Messing, Robert O: 1 article (09/2008)

Related Diseases

1.	Cardiotoxicity 10/18/2021 - "Oxidative deamination of norepinephrine by MAO generates H2O2 and the catecholaldehyde 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), the latter of which is a highly potent and reactive electrophile that has been linked to cardiotoxicity. "
2.	Parkinson Disease (Parkinson's Disease) 01/01/2004 - "Topics to be reviewed include: chemical synthesis and properties of DOPEGAL and DOPAL; in vitro and in vivo toxicity of CA aldehydes; subcellular mechanisms of toxicity; free radical formation by DOPEGAL versus DOPAL; mechanisms of accumulation of CA aldehydes in Alzheimer's disease (AD) and Parkinson's disease (PD) and potential therapeutic targets in Alzheimer's disease and Parkinson's disease."
3.	Necrosis 06/20/1997 - "However, the type of DOPEGAL induced cell death, whether necrosis or apoptosis, is not known. "
4.	Hyperalgesia 09/01/2008 - "Finally, intradermal injection of 3,4-dihydroxyphenylglycolaldehyde (DOPEGAL), a neurotoxic MAO-A catecholamine metabolite, produced robust mechanical hyperalgesia. "
5.	Alzheimer Disease (Alzheimer's Disease) 01/01/2004 - "Topics to be reviewed include: chemical synthesis and properties of DOPEGAL and DOPAL; in vitro and in vivo toxicity of CA aldehydes; subcellular mechanisms of toxicity; free radical formation by DOPEGAL versus DOPAL; mechanisms of accumulation of CA aldehydes in Alzheimer's disease (AD) and Parkinson's disease (PD) and potential therapeutic targets in Alzheimer's disease and Parkinson's disease."

Related Drugs and Biologics

1.	Monoamine Oxidase (MAO)
2.	3,4-dihydroxyphenylglycolaldehyde
3.	Norepinephrine (Noradrenaline)
4.	Free Radicals
5.	Catecholamines
6.	Aldehydes

Related Therapies and Procedures

1.	Intradermal Injections