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globalagliatin

glucokinase activator

Also Known As:

(1R,2S)-2-Cyclohexyl-1-(4-(cyclopropylsulfonyl)phenyl)-N-(5-((2-(1-pyrrolidinyl)ethyl)sulfanyl)-1,3-thiazol-2-yl)cyclopropanecarboxamide; LY2608204

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - globalagliatin: 1
  - Pyrrolidines: 115
    - globalagliatin: 1
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - globalagliatin: 1

Experts

1.	Chen, Juan: 1 article (12/2020)
2.	Chen, Yang: 1 article (12/2020)
3.	Ding, Sijia: 1 article (12/2020)
4.	Ding, Yu: 1 article (12/2020)
5.	Fu, Qi: 1 article (12/2020)
6.	Fu, Zhenzhen: 1 article (12/2020)
7.	Shao, Feng: 1 article (12/2020)
8.	Sun, Caixia: 1 article (12/2020)
9.	Xie, Lijun: 1 article (12/2020)
10.	Yang, Tao: 1 article (12/2020)

Related Diseases

1.	Insulin Resistance 12/01/2020 - "High-dose globalagliatin significantly increased the Matsuda index, indicating improved insulin resistance. " 12/01/2020 - "High-dose globalagliatin reduced plasma glucose, and improved insulin resistance. "
2.	Type 2 Diabetes Mellitus (MODY) 12/01/2020 - "The aim of this study was to assess the safety, pharmacokinetics, and pharmacodynamics of globalagliatin in Chinese patients with type 2 diabetes. " 12/01/2020 - "Globalagliatin was well tolerated and showed favorable pharmacokinetic profiles in Chinese patients with type 2 diabetes. " 12/01/2020 - "Safety, Pharmacokinetics, and Pharmacodynamics of Globalagliatin, a Glucokinase Activator, in Chinese Patients with Type 2 Diabetes Mellitus: A Randomized, Phase Ib, 28-day Ascending Dose Study."
3.	Hypertriglyceridemia 12/01/2020 - "Following once-daily titration with ascending doses of globalagliatin of 20-120 mg (stage I) and 80-320 mg (stage II) for 7 days, globalagliatin caused mildly high incidences of hypoglycemia and hypertriglyceridemia. "
4.	Hypoglycemia (Reactive Hypoglycemia) 12/01/2020 - "Following once-daily titration with ascending doses of globalagliatin of 20-120 mg (stage I) and 80-320 mg (stage II) for 7 days, globalagliatin caused mildly high incidences of hypoglycemia and hypertriglyceridemia. "

Related Drugs and Biologics

1.	Glucose (Dextrose)
2.	Glucokinase