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TSPO ligand MGV-1

18 kDa translocator protein (TSPO) ligand

Also Known As:

2-phenylquinazolin-4-yl dimethylcarbamate; MGV-1

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - TSPO ligand MGV-1: 3

Experts

1.	Gavish, Moshe: 2 articles (05/2021 - 01/2019)
2.	Weizman, Abraham: 2 articles (05/2021 - 01/2019)
3.	Zeineh, Nidal: 2 articles (05/2021 - 01/2019)
4.	Gabay, Martin: 1 article (05/2021)
5.	Kahana, Meygal: 1 article (05/2021)
6.	Nagler, Rafael M: 1 article (05/2021)
7.	Obeid, Fadi: 1 article (05/2021)
8.	Azrad, Maya: 1 article (01/2019)
9.	Veenman, Leo: 1 article (01/2019)
10.	Aga-Mizrachi, S: 1 article (01/2015)

Related Diseases

1.	Dyskinesias (Dyskinesia) 01/01/2015 - "Furthermore, in the R6-2 (transgenic mouse model for Huntington disease; Strain name: B6CBA-Tg(HDexon1)62Gpb/3J) transgenic mouse model for Huntington disease, derivatives of MGV-1 can increase lifespan by >20% and reduce incidence of abnormal movements. "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 01/30/2019 - "Due to their pronounced anti-inflammatory activity, 2-Cl-MGV-1 and MGV-1 may serve as potential therapeutics in neuroinflammatory and neurodegenerative diseases."
3.	Seizures (Absence Seizure) 01/01/2015 - "Indeed, we found in a rat model of systemic kainic acid injection that MGV-1 can prevent seizures, counteract the process of ongoing brain damage, including edema, and restore behavior defects to normal patterns. "
4.	Lung Neoplasms (Lung Cancer) 05/02/2021 - "Pretreatment with MGV-1 and 2-Cl-MGV-1 (25 µM), 24 h prior to CS exposure, differentially attenuated the CS-induced cellular insult as well as cell death in H1299 lung cancer cells. " 05/02/2021 - "The TSPO Ligands MGV-1 and 2-Cl-MGV-1 Differentially Inhibit the Cigarette Smoke-Induced Cytotoxicity to H1299 Lung Cancer Cells."
5.	Huntington Disease (Huntington's Disease) 01/01/2015 - "Furthermore, in the R6-2 (transgenic mouse model for Huntington disease; Strain name: B6CBA-Tg(HDexon1)62Gpb/3J) transgenic mouse model for Huntington disease, derivatives of MGV-1 can increase lifespan by >20% and reduce incidence of abnormal movements. "

Related Drugs and Biologics

1.	2-(2-chlorophenyl)quinazolin-4-yl dimethylcarbamate
2.	Smoke
3.	Ligands
4.	Kainic Acid (Kainate)

Related Therapies and Procedures

1.	Therapeutics