HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

CRTH2 antagonist CT-133

CRTH2 antagonist

Also Known As:

3-(Trifluoromethyl)phenylboronic acid; CT-133

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Acids: 53217
  - Noncarboxylic Acids
    - Boronic Acids: 200
      - CRTH2 antagonist CT-133: 2
- Boron Compounds: 91
  - Boronic Acids: 200
    - CRTH2 antagonist CT-133: 2
Organic Chemicals: 133
- Boron Compounds: 91
  - Boronic Acids: 200
    - CRTH2 antagonist CT-133: 2

Experts

1.	Agoni, Clement: 1 article (03/2020)
2.	Issahaku, Abdul Rashid: 1 article (03/2020)
3.	Kumi, Ransford O: 1 article (03/2020)
4.	Olotu, Fisayo A: 1 article (03/2020)
5.	Soliman, Mahmoud E S: 1 article (03/2020)
6.	Hussain, Musaddique: 1 article (07/2019)
7.	Lu, Meiping: 1 article (07/2019)
8.	Tang, Lanfang: 1 article (07/2019)
9.	Wu, Fugen: 1 article (07/2019)
10.	Wu, Junsong: 1 article (07/2019)

Related Diseases

1.	Hypoxia (Hypoxemia) 07/05/2019 - "LPS induced a significant secretion of PGD2 from primary macrophages, however, CT-133 dose-dependently and markedly decreased the infiltration of neutrophils and macrophages into lungs, reduced the IL-1β, TNF-α, IL-6, and KC levels in broncho-alveolar lavage (BAL) fluids, decreased the wet weight and myeloperoxidase activity of lungs, reduced Evans blue and albumin exudation into lungs, and improved the lung histopathological changes and hypoxemia. "
2.	Acute Lung Injury 07/05/2019 - "A CRTH2 antagonist, CT-133, suppresses NF-κB signalling to relieve lipopolysaccharide-induced acute lung injury." 03/01/2020 - "One of such inhibitors is the ramatroban analog, CT-133, which exhibited therapeutic potency cigarette smoke-induced acute lung injury in patients. "
3.	Lung Injury 07/05/2019 - "Thus, This is the first report that a CRTH2 antagonist, CT-133, is capable of significantly alleviating LPS-induced lung injury by probably down-regulating the NF-κB signalling."
4.	Inflammation (Inflammations) 03/01/2020 - "Lipid-Embedded Molecular Dynamics Simulation Model for Exploring the Reverse Prostaglandin D2 Agonism of CT-133 towards CRTH2 in the Treatment of Type-2 Inflammation Dependent Diseases."

Related Drugs and Biologics

1.	Prostaglandin D2
2.	Interleukin-6 (Interleukin 6)
3.	Peroxidase (Myeloperoxidase)
4.	Evans Blue (Blue, Evans)
5.	Albumins
6.	Smoke
7.	Lipopolysaccharides
8.	Lipids
9.	ramatroban