eluforsen

01/01/2020 - "We assessed the safety and tolerability, pharmacokinetics and exploratory measures of efficacy of inhaled eluforsen in cystic fibrosis (CF) patients homozygous for the F508del-CFTR mutation. "
10/01/2019 - "The Cystic Fibrosis-Like Airway Surface Layer Is not a Significant Barrier for Delivery of Eluforsen to Airway Epithelial Cells."
01/01/2020 - "Antisense oligonucleotide eluforsen is safe and improves respiratory symptoms in F508DEL cystic fibrosis."
10/01/2019 - "Background: Eluforsen (previously known as QR-010) is a 33-mer antisense oligonucleotide under development for oral inhalation in cystic fibrosis (CF) patients with the delta F508 mutation. "
01/01/2019 - "Antisense oligonucleotide eluforsen improves CFTR function in F508del cystic fibrosis."

01/01/2019 - "In vitro, the effect of eluforsen was investigated in human CF pancreatic adenocarcinoma cells and human bronchial epithelial cells. "
01/01/2019 - "In vitro, eluforsen improved chloride efflux in CF pancreatic adenocarcinoma cell cultures and increased short-circuit current in primary human bronchial epithelial cells, both indicating restoration of CFTR function. "