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YKL-05-099

a salt-inducible kinase (SIK) inhibitor

Also Known As:

3-(2-chloro-6-methylphenyl)-7-(2-methoxy-4-(1-methylpiperidin-4-yl)anilino)-1-(5-methoxypyridin-2-yl)-4H-pyrimido(4,5-d)pyrimidin-2-one

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - YKL-05-099: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - YKL-05-099: 2
  - Piperidines: 17
    - YKL-05-099: 2

Experts

1.	Gray, Nathanael S: 2 articles (01/2021 - 01/2020)
2.	Wang, Jinhua: 2 articles (01/2021 - 01/2020)
3.	Berdeaux, Rebecca: 1 article (01/2021)
4.	Blouin, Stephane: 1 article (01/2021)
5.	Bouxsein, Mary L: 1 article (01/2021)
6.	Brooks, Daniel J: 1 article (01/2021)
7.	Castro Andrade, Christian D: 1 article (01/2021)
8.	Foretz, Marc: 1 article (01/2021)
9.	Klaushofer, Klaus: 1 article (01/2021)
10.	Kronenberg, Henry M: 1 article (01/2021)

Related Diseases

1.	Disease Progression 01/01/2020 - "In this study, we evaluated whether inhibition of SIK3 with the tool compound YKL-05-099 can suppress MEF2C function and attenuate disease progression in animal models of AML. " 01/01/2020 - "Based on these findings, we treated 2 different mouse models of MLL-AF9 AML with YKL-05-099, which attenuated disease progression in vivo and extended animal survival at well-tolerated doses. "
2.	Bone Resorption 01/01/2021 - "Postnatal mice with inducible, global deletion of SIK2 and SIK3 show increased bone mass, increased bone formation, and, distinct from the effects of YKL-05-099, increased bone resorption. " 01/01/2021 - "Here, we report that YKL-05-099 increases bone formation in hypogonadal female mice without increasing bone resorption. "