MPAPO

12/01/2021 - "These results suggest that hypoxia induces oxidative stress, apoptosis, and neurites disruption, while MPAPO is remarkably protective against these adverse effects of hypoxia in TGCs and the developing retinas by specifically activating PAC1 receptor."
12/01/2021 - "Disordered retina was attenuated with MPAPO eye drops, as well as hypoxia-induced apoptosis in the developing retina, increase in LPO, and decrease in GSH levels and SOD activity of the retina. "
12/01/2021 - "In TGCs after hypoxia exposure, we discovered that reactive oxygen species level, the contents of cytosolic cytochrome c and cleaved-caspase-3 were significantly increased, in the meanwhile, m-Calpain was activated and cytoskeleton proteins (αII-spectrin and Synapsin) were degraded, neurites of TGCs disappeared, but these effects were reversed in TGCs treated with MPAPO. "

01/01/2019 - "MPAPO significantly promoted corneal wound repair in C57BL/6 mice. "
07/01/2015 - "C57BL/6 mice and Japanese white rabbits were respectively used to analyze the effects of MPAPO on corneal wound repairing and lacrimal fluid secretion. "
07/01/2015 - "The actions of MPAPO on corneal wound repairing and lacrimal secretion were examined. "
07/01/2015 - "MPAPO may represent a promising external therapeutic peptide for corneal wound repairing or dry eye."
07/01/2015 - "In experimental animals, MPAPO performed a complete corneal epithelial wound closure in 30 hours and significantly inhibited corneal neovascularization, and the effects were obviously stronger than for wild PACAP and recombinant bovine (rb)-bFGF (an anti-corneal wound drug). "

01/01/2019 - "To clarify the biological effects and molecular mechanisms of the pituitary adenylate cyclase activating polypeptide (PACAP)-derived peptide MPAPO (named MPAPO) to promote corneal wound healing, we applied a mechanical method to establish a corneal injury model and analyzed the repair effects of MPAPO on corneal injury. "

07/01/2015 - "In experimental animals, MPAPO performed a complete corneal epithelial wound closure in 30 hours and significantly inhibited corneal neovascularization, and the effects were obviously stronger than for wild PACAP and recombinant bovine (rb)-bFGF (an anti-corneal wound drug). "

07/01/2015 - "Furthermore, MPAPO can increase the lacrimal secretion, which may efficiently improve dry eye. "
07/01/2015 - "MPAPO may represent a promising external therapeutic peptide for corneal wound repairing or dry eye."