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GSK872

A selective RIP3 inhibitor

Also Known As:

4-quinolinamine, N-5-benzothiazolyl-6-((1-methylethyl)sulfonyl)-; N-(1,3-benzothiazol-5-yl)-6-(isopropylsulfonyl)-4-quinolinamine

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Benzothiazoles: 40
        GSK872: 14
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - GSK872: 14
    - Benzothiazoles: 40
      - GSK872: 14

Experts

1.	Gong, Xiufeng: 1 article (04/2022)
2.	He, Ming: 1 article (04/2022)
3.	Hu, Zhexuan: 1 article (04/2022)
4.	Li, Jingchi: 1 article (04/2022)
5.	Ma, Chengning: 1 article (04/2022)
6.	Wo, Lulu: 1 article (04/2022)
7.	Zhan, Mengna: 1 article (04/2022)
8.	Zhang, Xin: 1 article (04/2022)
9.	Zhao, Qian: 1 article (04/2022)
10.	Zhou, Cixiang: 1 article (04/2022)

Related Diseases

1.	Inflammation (Inflammations) 09/01/2021 - "Necrostatin-1 (Nec-1) and GSK872 reduced necrotic cell death, attenuated p-RIP3 and p-MLKL levels, slightly improved neurobehaviours and inhibited microglial and astrocyte activation and inflammation. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 08/01/2019 - "Moreover, GSK872 alleviated OGD-inducted mitochondrial dysfunction, decreased antioxidative capacity and cell death in spinal cord neurons, through inhibiting RIP3 activity. " 01/01/2023 - "The keywords in the search included: "necroptosis", "Alzheimer's disease", "signaling pathways", "Aβ", Aβo", "Tau", "p-Tau", "neuronal death", "BBB damage", "neuroinflammation", "microglia", "mitochondrial dysfunction", "granulovacuolar degeneration", "synaptic loss", "axonal degeneration", "Nec-1", "Nec-1s", "GSK872", "NSA", "OGA", "RIPK1", "RIPK3", and "MLKL". " 01/01/2021 - "Oxidative stress caused by UUO is tightly associated with endoplasmic reticulum stress and mitochondrial dysfunction, leading to apoptotic cell death through Wnt3α/β-catenin/GSK-3β signaling; all of which were abolished by both dapagliflozin and specific RIP inhibitors (necrostatin-1 and GSK872). "
3.	Hypoxia (Hypoxemia) 04/06/2022 - "Meanwhile, Necrostatin-1 and GSK872 could restore cell death of liver cancer cells caused by knockdown of HABON under hypoxia. " 11/01/2022 - "Our findings revealed that AZD5423 strongly inhibits activation of RIPK3, and MLKL phosphorylation upon cisplatin-, hypoxia/reoxygenation (H/R)- and TNF-α stimuli as compared with GSK872, which is a previously identified RIPK3 inhibitor. "
4.	Neuroinflammatory Diseases 01/01/2023 - "The keywords in the search included: "necroptosis", "Alzheimer's disease", "signaling pathways", "Aβ", Aβo", "Tau", "p-Tau", "neuronal death", "BBB damage", "neuroinflammation", "microglia", "mitochondrial dysfunction", "granulovacuolar degeneration", "synaptic loss", "axonal degeneration", "Nec-1", "Nec-1s", "GSK872", "NSA", "OGA", "RIPK1", "RIPK3", and "MLKL". " 10/26/2022 - "Administration of the RIP3 inhibitor GSK872 and RIP1 inhibitor necrostatin-1 (Nec-1) prevented glutamate-induced RGCs loss, retinal damage, neuroinflammation, overproduction of ROS and a decrease in GSH. "
5.	Lung Injury 01/01/2018 - "GSK872 significantly suppressed the activation of necroptosis and NLRP3 activation with reduction of IL-1β and IL-18 production and inflammatory cells infiltration, resulting in a significant amelioration of lung injury. "

Related Drugs and Biologics

1.	necrostatin-1
2.	Inflammasomes
3.	Catenins
4.	Interleukin-18 (Interleukin 18)
5.	Glutamic Acid (Glutamate)
6.	Neuroprotective Agents
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Cytokines
9.	Interleukin-6 (Interleukin 6)
10.	Superoxide Dismutase