tuftsin-phosphorylcholine

a novel helminth-based compound that modulates the host immune network

Networked: 10 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Pharmaceutical Preparations
- Drug Combinations: 5337
  - tuftsin-phosphorylcholine: 10
Organic Chemicals: 133
- Amines: 4871
  - Quaternary Ammonium Compounds: 136
    - Trimethyl Ammonium Compounds: 1
      - Choline: 6256
        Phosphorylcholine: 752
        tuftsin-phosphorylcholine: 10
- Onium Compounds
  - Quaternary Ammonium Compounds: 136
    - Choline: 6256
      - Phosphorylcholine: 752
        tuftsin-phosphorylcholine: 10
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        gamma-Globulins: 2960
        Tuftsin: 144
        tuftsin-phosphorylcholine: 10
        Immunoglobulin Fragments: 976
        Immunoglobulin Fab Fragments: 769
        Tuftsin: 144
        tuftsin-phosphorylcholine: 10
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        gamma-Globulins: 2960
        Tuftsin: 144
        tuftsin-phosphorylcholine: 10
        Immunoglobulin Fragments: 976
        Immunoglobulin Fab Fragments: 769
        Tuftsin: 144
        tuftsin-phosphorylcholine: 10
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        gamma-Globulins: 2960
        Tuftsin: 144
        tuftsin-phosphorylcholine: 10
        Immunoglobulin Fragments: 976
        Immunoglobulin Fab Fragments: 769
        Tuftsin: 144
        tuftsin-phosphorylcholine: 10
- Peptides: 82426
  - Oligopeptides: 519
    - Tuftsin: 144
      - tuftsin-phosphorylcholine: 10
  - Peptide Fragments: 373
    - Immunoglobulin Fragments: 976
      - Immunoglobulin Fab Fragments: 769
        Tuftsin: 144
        tuftsin-phosphorylcholine: 10

Experts

1.	Blank, Miri: 7 articles (02/2020 - 05/2015)
2.	Shoenfeld, Yehuda: 7 articles (02/2020 - 05/2015)
3.	Amital, Howard: 3 articles (02/2020 - 12/2019)
4.	Segal, Yahel: 3 articles (02/2020 - 12/2019)
5.	Bashi, Tomer: 3 articles (12/2019 - 05/2015)
6.	Volkov, Alexander: 3 articles (12/2019 - 05/2015)
7.	Fridkin, Mati: 3 articles (01/2019 - 05/2015)
8.	Abraham, Lital: 2 articles (02/2020 - 12/2019)
9.	Aharoni, Rina: 2 articles (02/2020 - 12/2019)
10.	Churilov, Leonid P: 2 articles (02/2020 - 12/2019)

Related Diseases

1.	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 02/15/2020 - "Corrigendum to "Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis" [J Neuroimmunol. " 12/15/2019 - "Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis." 12/15/2019 - "Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. " 12/26/2019 - "Previously, we have shown the efficacy of tuftsin-phosphorylcholine (TPC), based on a helminth product, in four animal models of autoimmune diseases: arthritis, colitis, systemic lupus erythematosus, and experimental autoimmune encephalomyelitis. "
2.	Arthritis (Polyarthritis) 01/01/2018 - "Helminths-based bi-functional molecule, tuftsin-phosphorylcholine (TPC), ameliorates an established murine arthritis." 12/26/2019 - "Previously, we have shown the efficacy of tuftsin-phosphorylcholine (TPC), based on a helminth product, in four animal models of autoimmune diseases: arthritis, colitis, systemic lupus erythematosus, and experimental autoimmune encephalomyelitis. "
3.	Autoimmune Diseases (Autoimmune Disease) 03/01/2019 - "Helminth-Related Tuftsin-Phosphorylcholine Compound and its Interplay with Autoimmune Diseases." 01/01/2017 - "Tuftsin-phosphorylcholine treatment of autoimmune diseases - a benefit and a message from helminths?" 12/26/2019 - "Previously, we have shown the efficacy of tuftsin-phosphorylcholine (TPC), based on a helminth product, in four animal models of autoimmune diseases: arthritis, colitis, systemic lupus erythematosus, and experimental autoimmune encephalomyelitis. "
4.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 12/26/2019 - "Previously, we have shown the efficacy of tuftsin-phosphorylcholine (TPC), based on a helminth product, in four animal models of autoimmune diseases: arthritis, colitis, systemic lupus erythematosus, and experimental autoimmune encephalomyelitis. "
5.	Inflammation (Inflammations) 12/15/2019 - "Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. "

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Related Therapies and Procedures

1.	Immunomodulation