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AUT00063

Kv3 potassium channel modulator

Also Known As:

(5R)-5-ethyl-5-methyl-3-(2-((4-methyl-3-((trifluoromethyl)oxy)phenyl)oxy)-5-pyrimidinyl)-2,4imidazolidinedione

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - AUT00063: 3
  - Pyrimidines: 510
    - AUT00063: 3

Experts

1.	Large, Charles H: 2 articles (01/2021 - 01/2019)
2.	Alvaro, Giuseppe S: 1 article (01/2021)
3.	Popelář, Jiří: 1 article (01/2021)
4.	Rybalko, Natalia: 1 article (01/2021)
5.	Svobodová Burianová, Jana: 1 article (01/2021)
6.	Syka, Josef: 1 article (01/2021)
7.	Šuta, Daniel: 1 article (01/2021)
8.	Daniel, Matija: 1 article (01/2019)
9.	Hall, Deborah A: 1 article (01/2019)
10.	Harris, Peter: 1 article (01/2019)

Related Diseases

1.	Tinnitus 01/01/2019 - "The main purpose of the QUIET-1 (QUest In Eliminating Tinnitus) trial was to examine the effect of AUT00063 on the severity of tinnitus symptoms in people with subjective tinnitus. " 01/01/2019 - "A balanced randomised placebo controlled blinded phase IIa multi-centre study to investigate the efficacy and safety of AUT00063 versus placebo in subjective tinnitus: The QUIET-1 trial." 01/01/2019 - "While the pharmacokinetic markers confirm the uptake of AUT00063 in the body, within the expected therapeutic range, with respect to clinical benefit findings indicated that AUT00063 was not effective in alleviating tinnitus symptoms (1.56 point change in Tinnitus Functional Index). " 01/01/2018 - "The purpose of this study was to test whether a Kv3 potassium channel modulator, AUT00063, has therapeutic potential for reversing noise-induced increases in spontaneous neural activity, a state that is widely believed to underlie noise-induced tinnitus. "
2.	Hearing Disorders (Hearing Disorder) 01/01/2021 - "These results indicate that AUT00063 and AUT00202 may influence intrinsic firing properties of neurons in the central auditory system of aged animals and have the potential to treat aged-related hearing disorders."

Related Drugs and Biologics

1.	Potassium Channels (Potassium Channel)